Journal of Advanced Biomedical Sciences
JABS
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URL: http://jabs.fums.ac.ir/article-1-242-en.html
, Shirzad Hosseini2 , Mojtaba Keshavarz * 3, Ahmad Mozafar4 , Mohammadhasaan Meshkibaf5 , Mohammadali Takhshid6
2- Department of Anatomy, School of Medicine Tehran, University of Medical Sciences, Tehran, Iran.
3- Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran. ,
4- Young Researchers and Elite Club, Science and Research Branch, Islamic Azad University, Fars, Iran.
5- Department of Biochemistry, Fasa University of Medical Sciences, Fasa, Iran.
6- Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Background &
Objective: Endosulfan is one of the strong insecticides used in agriculture.
This toxin is absorbed by inhalation and skin. Endosulfan has side effects such
as infertility in men. This study surveys the effect of vitamins E and C
on preventing the harmful effects of
Endosulfan on spermatogenesis in adult male rats.
Materials &
Methods: Adult male rats (200-250 g) from Wistar rats were divided into
five groups of 10 rats. Rats in the
experimental groups one, two, three, and four received 10 mg/kg Endosulfan
daily for 10 consecutive days via gavage. Moreover, during this period, rats of
group two in addition to daily Endosulfan,
received 20 mg / kg vitamin C daily, group three received 200mg / kg Vitamin E
daily and group four received20mg / kg kg vitamin C plus 200mg / kg Vitamin E
daily, by gavage. Control group received only routine food and water. At the
end of this period, sexual cells were counted by light microscope on testis
sections. The results were analyzed by
one-way ANOVA test and Duncan's test at p≤0.05.
Results: The
results showed that vitamins E and C have inhibitory effect on the degenerative
impact of Endosulfan on spermatogenesis.
Conclusion: The
results of this study indicated that Endosulfan impairs spermatogenesis by
increasing the oxidative stress. Vitamins E and C inhibit the degenerative
effects of Endosulfan on spermatogenesis by reducing the oxidative stress.
Received: 2013/10/21 | Accepted: 2014/04/18 | Published: 2014/09/18
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