Volume 4, Issue 2 (9-2014)                   JABS 2014, 4(2): 243-250 | Back to browse issues page

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haghbin M A, khosro zamiri H, shahabi M, shabani M, vahdani H. Evaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesia. JABS 2014; 4 (2) :243-250
URL: http://jabs.fums.ac.ir/article-1-176-en.html
Evaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesia
Mohammad ali Haghbin1 , Hamid Khosro zamiri2 , Marjan Shahabi2 , Mohammad Shabani * 3, Hamed Vahdani4
1- Department of Anesthesiology, Neurology Research Center, Kerman University Of Medical Science, Kerman, Iran
2- Department of Anesthesiology, Kerman University of Medical Science, Kerman, Iran
3- Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Science, Kerman, Iran , shabanimoh@yahoo.com
4- Kerman Health Center, Kerman University of Medical Science, Kerman, Iran
Abstract:   (8952 Views)
  Background &Objective: Plaryngoscopy and tracheal intubation increase not only blood pressure and heart rate but also Bispectral Index (BIS) of the patients. In this study, hemodynamic and BIS changes were surveyed after tracheal intubation and during general anesthesia followed by mexiletine prescription .

Materials & Methods: In this study, 50 patients aged between 20 and 60 who were candidates for orthopedic surgery of the upper limbs were surveyed. They were divided in two groups randomly. Two hours before induction of anesthesia,  case and control groups received mexiletine 200 mg as capsule and oral placebo, respectively. Systolic  and diastolic blood pressures ,heart rate, and BIS of both groups were compared before induction and intubation 1,3 and 10 minutes after intubation and immediately  , 15, 30, 45, and 60 minutes  after  surgical incision.

Results: There was not any significant differences in systolic and diastolic pressures of the two groups.  The heart rate was lower in mexiletine group compared to control group, 30 minutes after surgical incision and immediately after extubation (P<0.05). BIS was significantly more in mexiletine groupcompared to control group (p<0/05).

Conclusion: It was revealed that  the hemodynamic changes after laryngoscopy and during general anesthesia were significantly lower in mexiletine group compared to the  control group. It`s suggested that the prescription of this drug leads to the increase of BIS after intubation and during general anesthesia.

Keywords: Mexiletine, Bispectral Index (BIS), Hemodynamic Changes, Laryngoscopy and Tracheal Intubation
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Type of Study: Research | Subject: anesthesiology
Received: 2013/04/26 | Accepted: 2013/11/18 | Published: 2014/09/16
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