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:: Volume 4, Issue 3 (Autumn 2014) ::
J Fasa Univ Med Sci 2014, 4(3): 311-317 Back to browse issues page
Antibacterial Effect of Allicin, Silver Nano Particles, and Their Combination against Skin Infection due to Pseudomonas aeruginosa in Animal Model
Fatemeh Mirzaei1, Mojtaba Salouti 2, Reza Shapouri3, Hamed Alizadeh4
1- Department of Microbiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran.
2- Biology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran. , saloutim@yahoo.com
3- Biology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran.
4- Young Researchers and Elite Club, Zanjan Branch, Islamic Azad University, Zanjan, Iran.
Abstract:   (11480 Views)

Background & Objective: Common antibiotics may be useless against multiple pathogens because of the multidrug resistance. Therefore, new ways of nanotechnology and effective herbal combination can be the solution for this problem. The objective of this study is to investigate the antimicrobial effect of Allicin, silver nano particles and their combination against skin infection due to Pseudomonas aeruginosa in animal model.

Materials & Methods: In this experimental study, Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of Allicin, silver nano particles, and their combination were determined by macro dilution susceptibility test. Skin infection was produced in the shoulder region of 12 mice using Pseudomonas aeruginosa and the effect of ointment of Allicin, silver nano particles, and their combination were evaluated.

Results: The results showed that MIC and MBC of Allicin for pseudomonas aeruginosa were 2.38 and 4.77 mg/ml, respectively. MIC and MBC of silver nano particle for Pseudomonas aeruginosa were 3.12 and 6.25 ppm, respectively. MIC and MBC of combination of Allicin and silver nano particles on Pseudomonas aeruginosa were 0.59 mg/ml and 1.5 ppm, 1.19 mg/ml and 3.12 ppm, respectively. Anti-microbial effect of Allicin, silver nano particles and the synergistic activity of their combination against skin infections due to Pseudomonas aeruginosa was observed in animal model.

Conclusion: The results showed that Allicin in combination with silver nano particles have synergistic effect against skin infection due to Pseudomonas aeruginosa.

Keywords: Skin Infection, Pseudomonas aeruginosa, Allicin, silver Nanoparticles, Synergistic Effect
Full-Text [PDF 1028 kb]   (2228 Downloads)    
Type of Study: Research | Subject: Microbiology
Received: 2013/12/16 | Accepted: 2014/05/5 | Published: 2014/12/20
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Mirzaei F, Salouti M, Shapouri R, Alizadeh H. Antibacterial Effect of Allicin, Silver Nano Particles, and Their Combination against Skin Infection due to Pseudomonas aeruginosa in Animal Model. J Fasa Univ Med Sci. 2014; 4 (3) :311-317
URL: http://journal.fums.ac.ir/article-1-101-en.html


Volume 4, Issue 3 (Autumn 2014) Back to browse issues page
Journal of Fasa University of Medical Sciences
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