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:: Volume 8, Issue 2 (Summer 2018) ::
J Fasa Univ Med Sci 2018, 8(2): 795-804 Back to browse issues page
The effect of Panax ginseng extract on histomorphometric changes on brachial plexus region of the spinal cord in 20 days fetuses of diabetic rats
Azam Karami 1, Zabihollah Khaksar 2
1- Department of biology, Payamenoor university, Tehran, Iran , karami79@gmail.com
2- Department of Anatomy, Faculty of Veterinary, Shiraz University, Shiraz, Iran
Abstract:   (421 Views)
Background & Objective: Diabetes mellitus is a group of metabolic disorders characterized by increased levels of glucose. Ginseng has been used to control the diabetes for many years ago. This study investigated the effect of Panax ginseng extract on histomorphometric changes on brachial plexus region of spinal cord in 20 days fetuses of diabetic rats.
Material & Methods: 16 rats were divided into four groups: non-diabetic control, non-diabetic recipient of the extract, diabetic control and diabetic recipient of the extract. Diabetes was induced by streptozotocin in diabetic groups and all groups became pregnant. During pregnancy, recipient of the extract groups received ginseng extract every day. On the 20th day of pregnancy, the mothers were anesthetized, and the fetuses were obtained. Brachial region of the spinal cord with vertebral column separated after using the techniques of histology, some histological factors were measured. Data were analyzed by using SPSS software and ANOVA and Duncan statistical tests (P≤0.05).
Results: A significant difference was observed in the transverse and vertical diameter of central canal of the spinal cord in brachial plexus region of fetuses in diabetic control group than non-diabetic groups (P≤0.05). A significant reduction was observed in height of ependymal cells and cell count of gray matter of spinal cord in diabetic control group than other groups (P≤0.05).
Conclusion: Extract of Panax ginseng can control hyperglycemia and manage diabetes on spinal cord in fetuses of mothers with gestational diabetes by increasing β-cells stimulation and increasing insulin production.
 
Keywords: Diabetes mellitus, brachial plexus region of spinal cord, Panax ginseng extract, Streptozotocin, Rat
Full-Text [PDF 1094 kb]   (73 Downloads)    
Type of Study: Research | Subject: Histology
Received: 2017/10/10 | Accepted: 2018/03/4 | Published: 2018/09/16
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Karami A, Khaksar Z. The effect of Panax ginseng extract on histomorphometric changes on brachial plexus region of the spinal cord in 20 days fetuses of diabetic rats. J Fasa Univ Med Sci. 2018; 8 (2) :795-804
URL: http://journal.fums.ac.ir/article-1-1513-en.html


Volume 8, Issue 2 (Summer 2018) Back to browse issues page
Journal of Fasa University of Medical Sciences
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