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:: Volume 8, Issue 3 ( Autumn 2018) ::
J Fasa Univ Med Sci 2018, 8(3): 890-900 Back to browse issues page
Investigating the effects of Thymol on animal model of Rheumatoid Arthritis
Khadije Golbahari1 , Meysam Abtahi Froushani Seyyed 2
1- Urmia University
2- Urmia University , meysamabtahi@hotmail.com
Abstract:   (1839 Views)
BBackground & Objectives: Nowadays, attention to natural products with therapeutic potential has been increased. This study was carried out to investigate the effect of Thymol on the animal model of Rheumatoid arthritis (RA).
Materials & Methods: RA was induced by injection of complete Freund's adjuvant into the footpad of Wistar rats. Then, rats were allocated in 3 groups: treated with Thymol (100 mg/kg-orally), treated with Prednisolone (100 mg/kg-orally) and un-treated group. All treatments were initiated at the 5th day after induction. The change in the dorso-plantar diameter of hands and legs of each rat were recorded every other day until 23 days after induction.
Results: The edema and swelling of the soles of the feet of RA rats that received Thymol or prednisolone, were significantly decreased in a similar manner compared to RA rat without treatment. The serum levels of nitric oxide and myeloperoxidase correlated with the proliferation of spleen lymphocytes and the levels of IL-1 and IL-6 production were significantly decreased in treatment groups compared to control group rats. The level of decrease in the level of serum nitric oxide was higher in the thymol group compared to the prednisolone-induced group. Conversely, prednisone caused more decrease in the levels of IL-1 and IL-6 cytokines compared to RA rats that received thymol.
Conclusion: Thymol may be considered as a useful strategy to control RA disease.
Keywords: Thymol, Rheumatoid Arthritis, Immunity Responses
Full-Text [PDF 1188 kb]   (384 Downloads)    
Type of Study: Research | Subject: Immunology
Received: 2018/02/4 | Accepted: 2018/06/8 | Published: 2018/12/22
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golbahari K, Abtahi Froushani M. Investigating the effects of Thymol on animal model of Rheumatoid Arthritis. J Fasa Univ Med Sci. 2018; 8 (3) :890-900
URL: http://journal.fums.ac.ir/article-1-1557-en.html


Volume 8, Issue 3 ( Autumn 2018) Back to browse issues page
Journal of Fasa University of Medical Sciences
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