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:: Volume 9, Issue 4 (Winter 2019) ::
J Fasa Univ Med Sci 2019, 9(4): 1903-1912 Back to browse issues page
The Effect of Endurance Training and L-Carnitine Consumption on TNF-a and IL-1β Gene Expression of Heart Tissue in Wistar Male Rats following Anabolic Steroid Consumption (Boldenone)
Pooran Adyani1 , Asieh Abbassi-Daloii 2, Saeedeh Shadmehri3
1- . Department of Sport Physiology, Ayatollah Amoli branch, Islamic Azad University, Amol
2- Department of Sport Physiology, Ayatollah Amoli branch, Islamic Azad University, Amol , abbasi.daloi@gmail.com
3- Department of Physical Education and Sport Science, Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran
Abstract:   (766 Views)
 Background & Objective: The aim of this study was to investigate the effect of endurance training and L-carnitine consumption on TNF-a and IL-1β gene expression of heart tissue in Wistar male rats following anabolic steroid consumption (Boldenone).
Materials & Methods: In this experimental study, 30 male Wistar rats aged 12 weeks (weight 195±7.94g) were randomly divided into five groups including control, no-treatment, boldenone (5mg/kg), L-carnitine and aerobic training- L-carnitine. The endurance moderate intensity training program (55-50% of maximal oxygen consumption) was performed for 6 weeks and 5 times a week. Injection was conducted once a week, on an appointed day, and in the quadriceps and hamstring it was conducted in depth. After anesthesia, autopsy was performed and the heart was isolated. The TNF-α and IL-1β gene expression in the samples was measured by Real Time PCR. Data were analyzed using t-test, One-way ANOVA and post hoc Scheffe at the significant level of P<0.05.
Results: The results showed that there was a significant difference between the mean TNF-α and IL-1β gene expression of heart tissue in male Wistar rats in different groups (P=0.001). The changes in TNF-α and IL-1β gene expression of heart tissue in L-carnitine and Training-L-carnitine groups were significantly lower than those of the no-treatment and boldenon groups (P=0.001).
Conclusion: It seems that supplementation of L-carnitine with regular aerobic training reduces heart tissue damage induced by anabolic androgenic steroids.
 
Keywords: Aerobic training, Boldenone, L-carnitine, TNF-α, IL-1β
Full-Text [PDF 757 kb]   (107 Downloads)    
Type of Study: Research | Subject: Immunology
Received: 2018/12/23 | Accepted: 2019/07/6 | Published: 2020/03/15
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adyani P, Abbassi-Daloii A, shadmehri S. The Effect of Endurance Training and L-Carnitine Consumption on TNF-a and IL-1β Gene Expression of Heart Tissue in Wistar Male Rats following Anabolic Steroid Consumption (Boldenone). J Fasa Univ Med Sci. 2019; 9 (4) :1903-1912
URL: http://journal.fums.ac.ir/article-1-1911-en.html


Volume 9, Issue 4 (Winter 2019) Back to browse issues page
Journal of Fasa University of Medical Sciences
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