[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Submit :: Contact Us ::
:: Volume 9, Issue 4 (Winter 2019) ::
J Fasa Univ Med Sci 2019, 9(4): 1829-1836 Back to browse issues page
The Evaluation of VE-Cadherin Gene Expression in Serum of Iranian Women With Breast Cancer
Narjes Asghari1 , Vajiheh Zarrinnpour1 , Abdolreza Daraei 2, Zahra Hajebrahimi3 , Dariush Moslemi4
1- Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
2- Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran , a.daraei@mubabol.ac.ir
3- Aerospace Research Institute, Ministry of Science Research and Technology, Tehran, Iran
4- Division of Radation Oncology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
Abstract:   (1100 Views)
Background & Objective: Breast cancer is one of the most common cancers and the second leading cause of cancer death in women worldwide, in both developed and developing countries.  Vascular endothelial (VE)-cadherin is endothelial specific adhesion molecule located at junctions between endothelial cells and its association with various cancers has been proven. The aim of this study was to evaluate the VE-cadherin gene expression in serum of Iranian women with breast cancer in order to identify a biomarker for its prediction.
Materials & Methods: After serum isolation from blood samples of the patients and controls, extraction of RNA and synthesis of cDNA were done. Gene expression was measured using real-time PCR technique.
Results: Our results showed that the expression of VE-cadherin was increased significantly in patients compared to control samples. However, there was no relationship between its expression and grade of the tumors.
Conclusion: Based on the results of this study, expression of this factor can be used as a marker for study and follow-up of breast cancer patients. Furthermore, considering the role of this factor in angiogenesis and metastasis, it can be used as a target for intervention therapy.

Keywords: breast cancer, evaluation of gene expression, VE-cadherin gene, serum biomarker
Full-Text [PDF 590 kb]   (115 Downloads)    
Type of Study: Research | Subject: Medical Genetics
Received: 2019/04/23 | Accepted: 2019/06/2 | Published: 2020/03/15
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Asghari N, Zarrinnpour V, Daraei A, Hajebrahimi Z, Moslemi D. The Evaluation of VE-Cadherin Gene Expression in Serum of Iranian Women With Breast Cancer. J Fasa Univ Med Sci. 2019; 9 (4) :1829-1836
URL: http://journal.fums.ac.ir/article-1-2010-en.html

Volume 9, Issue 4 (Winter 2019) Back to browse issues page
Journal of Fasa University of Medical Sciences
Persian site map - English site map - Created in 0.06 seconds with 32 queries by YEKTAWEB 4162