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:: Volume 9, Issue 4 (Winter 2019) ::
J Fasa Univ Med Sci 2019, 9(4): 1736-1742 Back to browse issues page
Assessment of Changes in Serum Concentrations of Liver Function (ALT, ALP, AST, LDH, GGT) After the Intake of Narcissus Bulbs
Hassan Morovvati 1, Nezam Armand2
1- Department of Basic Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran , hmorovati@ut.ac.ir
2- Department of Basic Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Abstract:   (635 Views)
Background & Objective: Narcissus bulb is an antiphlogistic drug, effective for asthma treatment, shortness of breath and skin burns. The aim of this study was to investigate the effect of Narcissus tazetta bulb extract on serum concentrations of liver function test enzymes (ALT, ALP, AST, LDH, GGT) in male rats.
Materials & Methode: In this study, 20 male rats were divided into 4 groups of 5 series. They were divided into control groups and experimental groups and received the alcoholic extract 50, 100 and 150 mg/kg of  Narcissus bulb. The extract was fed for 6 days and blood samples were taken from the animals on the seventh day and serum levels of liver enzymes were measured. Statistical analysis was performed with SPSS software (version 21.0) using t-test.
Results: The activity of Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) enzymes in 150 mg/kg extract of Narcissus bulb significantly increased (P<0.01). Also, at the same dose, the enzymes of Alkaline phosphatase (ALP), Lactate Dehydrogenase (LDH) and Gamma Glutamyl Transferase (GGT) showed a significant increase compared to the control group (P<0.05). ALT at 100 - mg/kg dose significantly increased, but AST at 50 mg/kg dose showed a significant decrease compared to the control group (P<0.05).
 Conclusion: Considering the significant increase in liver enzymes at high doses of extract, it is necessary to study the histopathological effects of the extracts of this plant on liver.
 
Keywords: Narcissus, Rat, liver enzyme
Full-Text [PDF 668 kb]   (108 Downloads)    
Type of Study: Research | Subject: Pharmaceutical Plants
Received: 2019/11/11 | Accepted: 2020/01/5 | Published: 2020/03/15
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morovvati H, armand N. Assessment of Changes in Serum Concentrations of Liver Function (ALT, ALP, AST, LDH, GGT) After the Intake of Narcissus Bulbs. J Fasa Univ Med Sci. 2019; 9 (4) :1736-1742
URL: http://journal.fums.ac.ir/article-1-2169-en.html


Volume 9, Issue 4 (Winter 2019) Back to browse issues page
Journal of Fasa University of Medical Sciences
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