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:: Volume 2, Issue 1 (Spiring 2012) ::
J Fasa Univ Med Sci 2012, 2(1): 1-5 Back to browse issues page
Evaluation of Th1 and TH2 Cytokine Network in Aspergilus Infected Tumor Bearing Mice
Noushin Sohrabi 1, Majid Tebyanyan, Mehdi Mahdavi
1- , nsohrabi75@yahoo.com
Abstract:   (16834 Views)

Background & Objective: Invasive Aspergillosis is a fatal infection in immunocompromised patients. The aim of this study was to evaluate the interaction of infectious with Aspergillus and tumor on immune response and cytokine network in Aspergillus infected tumor-bearing mice. Materials and Methods: Mice were implanted by sterile pieces of mouse mammary tumor and then infected by Aspergillus conidia by IV injection. Control groups mice were infected with Aspergillus conidia and/or implanted by sterile funga pieces of mouse mammary tumor. Seven days after Aspergillus infection, cytokine production of extracted splenocytes was analyzed by ELISA method.

Results: Tumor bearing mice which were infected with Aspergillus conidia showed remarkable increase in IL-4 production. Conversely, the levels of IFN-γ and IL-10 were decreased and TNF-α was increased moderately.

Conclution: Probably, Aspergillus infection could change cytokine production from CD4+ T helper cells and acquired immunity of tumor bearing mice. This point may be considered for better management of Aspergillus-infected patients suffering from cancer.

Keywords: Aspergillosis, Tumor bearing mice, Th1, Th2, Cytokines
Full-Text [PDF 1157 kb]   (2843 Downloads)    
Type of Study: Research | Subject: Immunology
Received: 2013/02/11 | Accepted: 2013/09/14 | Published: 2013/09/14
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Sohrabi N, Tebyanyan M, Mahdavi M. Evaluation of Th1 and TH2 Cytokine Network in Aspergilus Infected Tumor Bearing Mice. J Fasa Univ Med Sci. 2012; 2 (1) :1-5
URL: http://journal.fums.ac.ir/article-1-66-en.html


Volume 2, Issue 1 (Spiring 2012) Back to browse issues page
Journal of Fasa University of Medical Sciences
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