Showing 10 results for Bagheri
Padideh Ebadi, Ramin Yaghobi, Fataneh Eftekhar, Kambiz Bagheri,
Volume 1, Issue 3 (12-2011)
Abstract
Background & Objectives: Recurrent spontaneous abortion occurs by different etiological causes including viral infections. Cytomegalovirus and rubella infections can cause or promote the recurrent fetal loss. Cytomegalovirus is one of the important viral infections which may play a role in recurrent spontaneous abortion. Also, rubella virus infection can induce abortion especially in the first trimester of pregnancy. Thus, in this study the prevalence of anti-cytomegalovirus and rubella IgG antibody are measured in both pregnant women with and without recurrent spontaneous abortion.
Materials & Methods: A case-control study was carried out on 120 women who had a history of unexplained recurrent spontaneous abortion and 120 pregnant women with normal delivery as controls. Serum samples from each group were collected and anti-cytomegalovirus and rubella IgG antibody were assayed by ELISA methods.
Results: Anti-cytomegalovirus antibody was diagnosed in 94 and 75 of each group of patients or controls respectively. The Significant differences are as follows (P=0.007 OR=2.17 95%CI=1.18-4.00). Also, Anti-rubella antibody was diagnosed in 90 and 65 of 120 patients or controls, respectively. The significant differences are (P=0.00004 OR=3.00 95% CI=1.69-5.33) when compared with each other. Conclusion: Based on the high prevalence of cytomegalovirus and rubella infection in our community, especially in pregnant women, also according to this study, the significant differences were found between the prevalence of these viruses in pregnant women with recurrent abortion and pregnant women without the history of abortion. To reach to a concrete conclusion, further studies with larger population should be carried out.
Kambiz Bagheri, Ramin Yaghobi, Mohammad Hosein Karimi, Mitra Mirzaei, Mani Ramzi,
Volume 1, Issue 3 (12-2011)
Abstract
Background & Objectives: Hepatitis type G virus (HGV) is a flavivirus with RNA genome which has high nucleotide and amino acid similarity with HCV. HGV can infect blood lymphocytes for long period and may have role in inducing or complicating the clinical outcomes in patients with hematological malignancies. Therefore in this study the prevalence of HGV, HCV, and HBV infections were evaluated in patients with hematological malignancies.
Materials & Methods: In this study EDTA treated blood samples were collected from 100 patients with hematological malignancies and 110 healthy controls of southern cities of Fars province (Lar, Lamerd, Grash) Iran. The serologic and molecular markers of HGV, HCV, and HBV were analyzed by ELISA and PCR and RT-PCR methods, respectively in Hematology Research Center and Transplant Research Center, Namazi hospital, Shiraz University of Medical Sciences. Also the role of some risk factors in pathogenesis of these hepatitis viruses was studied statistically.
Results: Antibody against E2 antigen of HGV was diagnosed in 5% and 1.1% of patients with hematological malignancies and healthy controls, respectively. Significant difference was found between the prevalence of HGV antibodies in patients with hematological malignancies and healthy controls (P=0.037). The HCV antibody and prevalence of HCV- RNA was detected in 7% and 4% of patients with hematological malignancies respectively. Significant difference was found between the prevalence of HCV-RNA in patients with hematological malignancies and healthy controls (P=0.02). Also HBV viremia was found in 2% of patients.
Conclusion: In this study the significant presentation of HGV and HCV were found in patients with hematological malignancies compared with healthy controls. However, the results suggest that similar study should be carryout to evaluate the prevalence of this viral infection in other part of Iran, to control the spreading of these infections to other people.
M Rahmati, A Kazemi, M Bagherian Rafsanjani, J Taherabadi, M Madahi,
Volume 5, Issue 3 (11-2015)
Abstract
Background & Objectives: Painful neuropathy is a state resulting from somatosensory disease or injury. Neurotrophins such as NT-4 are crucial for neural growth and development and protect the integrity of function and structure of nervous system. Paying heed to the importance of physical activity in neural plasticity, this study focuses on the investigation of chronic effect of decreased activity on the form of spinal nerve ligation on NT-4 gene expression of male Wistar rat’s sciatic nerve fiber.
Materials & Methods: Ten adult male Wistar rats in the weight range of 250±30 gr were randomly divided into two groups, including one healthy control group (C) and one group with decreased physical activity (SNL). Over six weeks, neuropathic pain behavior tests were conducted continually in both groups. At the end of the sixth week, the changes in NT-4 gene expression in sciatic nerve were measured with Real time technique.
Results: The behavioral tests demonstrated that spinal nerve ligation induced thermal hyperalgesia and mechanical allodynia in the SNL group. Decreased pain threshold was observed throughout the study period (p<0.05). Additionally, in comparison with the C group, NT-4 gene expression in sciatic nerve fiber was significantly higher in the SNL group (p<0.05).
Conclusion: In the present study, it was discovered that the decreased activity in the form of SNL is associated with increased NT-4 gene expression in the experimental group. With respect to the physiologic functions of NT-4 in nervous system, this elevation is probably a mechanism for neurogenesis in the injured area, and based on the previous studies, it seems that the increased activity could enhance the increased NT-4 gene expression and accelerate neurogenesis.
Aboutaleb Bagheri, Nader Shakeri, Hojatollah Nik Bakht,
Volume 9, Issue 3 (9-2019)
Abstract
Background &Objective: Shift work can be a factor in inflammation, hypertension and cardiovascular diseases. The purpose of the present study was to evaluate the effect of 8-week aerobic physical activity on Hs-CRP and blood pressure of the shift workers of Sarir Plast Industrial Group in Dezful.
Materials & methods: The present research is a semi-experimental research that was carried out at the shift workers of the five industrial group of Surirplast. 30 workers, who had an average of 5 years of shift work history, were selected using judgmental sampling technique and were then randomly assigned to the two groups of aerobic physical activity (n=15) and control group (n=15). The experimental group performed 8 weeks, 3 sessions per week with 50-70% THR intensity, according to the schedule. Before and after the plan, the activity, height, BW, BMI, WHR, BFP, VF, Hs-CRP, SBP, DBP and HR were measured. For data analysis, Kolmogorov-Smirnov test, Leven test, Mbox-test and ANCOVA were used (p<0.05).
Results: The BW, BMI, WHR, BFP, and VF decreased significantly in the post test for the training group, while the value of Vo2max increased (p<0.05). Also, the results of the study indicated that APA had a significant effect on BW, BMI, WHR, BFP, VF, Hs-CRP, SBP, DBP, and HR.
Conclusion: 8-week Aerobic physical activity was effective in reducing the risk factors of CVD in shift workers; perhaps aerobic physical activity could be used as a non-pharmacological approach to prevent CVD in shift workers.
Mohammadjavad Hosseinpoor, Hamid Parvin, Samad Nejatian, Vahideh Rezaee, Karamollah Bagherifard,
Volume 10, Issue 1 (4-2020)
Abstract
Background & Objective: Nowadays, in medical sciences, the amount of data on symptoms of people affected with various illnesses on one hand, and finding assistive techniques for the diagnosis of those diseases on the other, has been widespread. Consequently, the analysis and consideration of all factors involved in a disease are often challenging. Thus, a mechanized system to help discover the rules, identify patterns, and predict future events is absolutely needed. In this research, we intend to use a multi-objective algorithm to provide a method capable of detecting, extract sequences of variable-length from the genome, and count the interactions among them. In fact, these regulatory elements could play a significant role in the incidence and exacerbation of cancer.
Material & Methods: In this research, a proposed method for the detection of regulatory elements in the genome of a breast cancer patient has been used. The proposed method is implemented in MATLAB software. Also, to measure the performance and effectiveness of the suggested method, the proposed algorithm is implemented on HiC dataset, regarding patients with breast cancer in two blood cells GM12878 and CD34+ introduced by Mifsud et al.
Results: The results of implementing the proposed method are compared with the HiCUP method. The results show that the MSARE method has a better performance in detecting regulatory elements compared to the HiCUP method.
Conclusion: Experimental studies have shown that the two promoters BLC6 and HOTTIP discovered by the proposed method have had a significant effect on the incidence and severity of breast cancer in both blood cells GM12878 and CD34+.
Pezhman Bagheri, Mouhebat Vali, Zahra Maleki,
Volume 10, Issue 1 (4-2020)
Abstract
Background & Objectives: The analysis of sleep patterns, food and physical activity provides researchers with a focus on chronic disease prevention. The aim of this study was to determine the dominant patterns of food, sleep and physical activity and related factors in Fasa in 2017.
Materials & Methods: In this cross-sectional study, 500 adults in Fasa were collected by multi-stage cluster sampling using a combination of Pittsburgh Sleep Quality Questionnaire, food Frequency and International Physical Activity Questionnaire. Factor analysis was used to identify the dominant patterns and in order to determine the relationship between variables, linear regression test was used.
Results: The mean age of the participants was 35.02 ± 12.68 years. The three dominant food patterns were healthy (24.35%), unhealthy (18.31%) and miscellaneous (12.98%), sleep disorders including primary sleep disorder (17.90%), secondary (16.60%) and third (12.46%) and physical activity also included light physical activity (37.09%), moderate (5.86%) and severe (16.26%). Also, variables such as age, gender and socioeconomic status were introduced as the main predictors of patterns.
Conclusion: Considering the high share of unhealthy patterns in the population of the city as an example of the urban population of southern Iran, the need for planning and raising awareness and education in order to increase physical activity and improve sleep and nutrition, as well as improve the quality of life and general health of individuals in society is increasingly felt.
Pejman Bagheri, Zahra Akbarzadeh, Zahra Maleki,
Volume 10, Issue 2 (6-2020)
Abstract
Background & Objective: Modern human suffers from a kind of religious non-alignment along with a health crisis. The aim of this study was to investigate the relationship between religious commitment and commitment to health behaviors with the aim of highlighting the role of spirituality crisis in a health crisis.
Materials & Methods: This cross-sectional study was conducted and 310 people in the city of Fasa over 18 years, were randomly selected and then, Worthington religious commitment questionnaire as well as the self-made questionnaire for their commitment to health behavior were completed. Data were analyzed using multiple linear regression and Pearson correlation coefficient by SPSS software version 22 and STATA version 13.
Results: Multiple linear regression analysis showed that crude and adjusted odds ratio of religious commitment in a prediction of commitment to health were 1.53 and 1.68 respectively. Among four independent variables, education, gender, and occupation were not good predictors for health commitments (P> 0.05) and only age was significant (p<0.05).
Conclusion: It seems that in the current situation, the commitment to health behaviors is a consequence of the commitment to religious behavior and other factors. Therefore, the combined role of religious commitment and other factors should not be overlooked in the pathology of health behaviors.
Pezhman Bagheri, Mousa Ghelichi Ghojogh, Vajihe Armanmehr, Ali Delshad Noghabi, Mahdi Moshki, Noorallah Moradi,
Volume 11, Issue 4 (11-2021)
Abstract
Background & objectives: Emotional divorce, seems to be a reducing factor in the quality of marital life and mental health. This study aimed to design, construct and validate an emotional divorce instrument.
Materials & Methods: This study was an applied, psychometric survey using a multi-stage sampling method conducted on 805 women living in Iran between 2015 to 2018. After determining the items in a semi-structured qualitative study, face, content, structure, and concurrent validity as well as the split-half and Cronbach's alpha coefficient methods for reliability evaluation were used. For all analyses, the SPSS19 software (IBM Corp, 2013) and for confirmatory factor analysis (CFA) LISREL 8.8 was used.
Results: 36.81% of the total variance was justified by 63 factors with Eigenvalues of less than 1 and 63.19% by the first 12 factors with an Eigenvalue of higher than 1. The final questionnaire consisted of 66 questions. The total Cronbach’s alpha coefficient was 0.979. The exploratory factor analysis (EFA) resulted in five factors consisting of "love and interest in the spouse", "attention to the needs and practice the tasks", "controversy and misbehavior", "mental health", and "respect and appreciation". The results of the CFA confirmed model derived from the EFA (Chi-Square=7653.70, df =2503, P-value= 0.0000, RMSEA = 0.051).
Conclusion: The reliability of this questionnaire was high in two consecutive evaluations. The structural validity also led to the identification of the desired number of items. Hence, this questionnaire seems to be an appropriate tool for assessing emotional divorce as a feature of quality of marital life. However, further investigation is needed for tool efficiency assessment in different communities.
Gholam Reza Bagheri, Hamid Reza Ghaffari, Majid Valizadeh, Hossein Ali Jahantigh, Marzieh Poursamimi, Hosein Shahriari, Javad Poursamimi,
Volume 13, Issue 2 (5-2023)
Abstract
Background & Objective: Gamma rays are widely used in medicine despite their harmful effects on health. Our study evaluated the protective effects of melatonin on kidney, heart, and liver tissues.
Materials & Methods: Seventy-two adult male Wistar rats were categorized into nine groups. Groups 2 and 3 only received whole-body γ-ray irradiation (WBI) (2.0 Gy), no melatonin, interval time (IT) 8hr and 24hr. Groups 4 and 5 received WBI (8.0 Gy, no melatonin, 8hr and 24hr). Groups 6 and 7 received melatonin at 60 minutes (min) before WBI(2.0 Gy). Groups 8 and 9 received melatonin before WBI(8.0 Gy). All the rats were sacrificed 8 or 24 h after the experiments for laboratory and histopathological analysis. Serum levels of Blood Urea Nitrogen(BUN), Creatinine (Cr), Lactate dehydrogenase (LDH), Potassium (K), Gamma-glutamyl Transferase (GGT), Serum Glutamic-Oxaloacetic Transaminase(SGOT), Serum Glutamic-Pyruvic Transaminase(SGPT), Alkaline Phosphatase(ALP), c-reactive protein(CRP), Troponine(TPO) and histological features of liver, heart and kidney tissues were assessed. Statistical analysis was performed by One-Way ANOVA.
Results: Our data did not indicate significant differences in BUN, Cr, K, and CRP between groups with or without melatonin treatment (P>0.05); but differences were significant for LDH, GGT, SGOT, SGPT, ALP, and TPO (P<0.05). The results showed that radiation-induced histopathological effects on the liver, heart, and kidneys were mitigated in the groups six to nine.
Conclusion: The existence of significant differences in serum levels of LDH, GGT, SGOT, SGPT, ALP, and TPO in groups(6 to 9) and amelioration of the histopathological effects of irradiation on the liver, heart, and kidneys in the groups six to nine showed that the melatonin(100 mg/kg) is able to protect the body in gamma-radiation(2.0 Gy and 8.0 Gy).
Hossein Kashirifar, Keyvan Kiakojouri, Saeid Mahdavi Omran, Akbar Hoseinnejad, Jalal Jafarzadeh, Ahmad Reza Aminian, Mohammad Jahangiri, Soghra Bagheri, Mojtaba Taghizadeh Armaki,
Volume 13, Issue 4 (9-2023)
Abstract
Background & Objective: Candida species are one of the most common causes of otomycosis. Antifungal drugs commonly used in treatment often have a variety of side effects, including toxicity, cross-reactivity, and drug resistance. In recent years, along with the advances in nanotechnology and the motivation to find new antifungal drugs, there has been a growing interest in the use of nanoparticles such as nano-curcumin in the treatment of fungal infections. The aim of this study was to evaluate the antifungal sensitivity of nano-curcumin on Candida species isolated from otomycosis.
Materials & Methods: In this experimental study, 100 isolated Candida samples from patients with otomycosis were included. Synthesis of nano-curcumin using chitosan (CS) nanoparticles was performed by ionic gelation method. Antifungal susceptibility testing was performed using broth microdilution method according to CLSI-M27-S4 guidelines on all Candida isolates to miconazole, clotrimazole and nanocurcumin. Data were analyzed in SPSS 27 software with independent t-test and chi-squared tests.
Results: Curcumin nanoparticles showed antifungal activity against all Candida species. However, the mean MIC of miconazole and clotrimazole for different Candida species was significantly lower than curcumin nanoparticles, indicating the lower antifungal effect of nano-curcumin than these two antifungals. Also, the mean MIC of nano-curcumin was not significantly different among Candida species (P < 0.05), whereas it was significantly different for miconazole and clotrimazole (P < 0.05).
Conclusion: The results of the present study showed that nano-curcumin had a lower antifungal effect than miconazole and clotrimazole, but due to nano-curcumin's safety, it can be used as a potential antifungal drug for the treatment of otomycosis after further investigation.
