Background & Objective: Adaptations in neuromuscular system are due to changes in the expression and activity of proteins and its transmitters. JIP 3 protein plays a role in the regulation of structure and function of neurons as well as the establishment of multi-nuclear muscle cells. Considering the effects of exercise on neuromuscular system, the present study aimed to investigate the effects of 6 weeks of endurance training on JIP3 gene expression in soleus muscle of male Wistar rats.

Material & Methods: Ten Wistar male rats were randomly assigned in two groups: trained and control. Endurance training protocol was performed for 6 weeks. Forty eight hours after final training session, the rats were dissected, and soleus muscle was removed. JIP3 gene expression was performed through Real Time PCR method.

Results: Endurance training increased JIP3 gene expression significantly compared to the control group.

Conclusion: It appears that a period of endurance training increases intramuscular gene expression of JIP3 through this can lead to a better consistency and functionality in the muscles.