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:: Volume 7, Number 2 (Summer 2017) ::
J Fasa Univ Med Sci 2017, 7(2): 162-171 Back to browse issues page
Mechanisms Involved in Immunopathogenesis of influenza virus infection
Ahmad Tavakoli1, Mohammad Hadi Karbalaie Niya1, Mohsen Keshavarz1, Hadi Ghaffari1, Maryam Esghaei 2
1- Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran , maryam.esghaei@gmail.com
Abstract:   (399 Views)

Influenza epidemics and pandemics cause notable morbidity and mortality.  Mortality cases are mostly associated with immunopathogenic mechanisms, although still poorly understood. Human studies help to understand the immunopathogenesis of influenza. However, there is limited information in this regard. Recent studies using experimental animal models have significantly improved our knowledge on complex mechanisms involved in the immunopathogenesis during influenza infections including acute inflammatory responses of neutrophils, dendritic cells, macrophages, toll-like receptors, chemokines, cytokines, CD4+ and CD8+ T cells. Due to influenza infection, elevated levels of cytokines and chemokines are produced during influenza-induced inflammation which are known as cytokine storm which is a severe immune response characterized by the recruitment of inflammatory leukocytes and increased levels of cytokines and chemokines at the site of infection. This review aimed to discuss the most recent findings on mechanisms of influenza immunopathogenesis.
 

Keywords: Influenza, Immunopathogenesis, Innate immunity, Adaptive immunity, Antiviral immune response
Full-Text [PDF 838 kb]   (142 Downloads)    
Type of Study: Review | Subject: Virology
Received: 2016/08/26 | Accepted: 2017/01/20 | Published: 2017/09/4
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Tavakoli A, Karbalaie Niya M H, Keshavarz M, Ghaffari H, Esghaei M. Mechanisms Involved in Immunopathogenesis of influenza virus infection . J Fasa Univ Med Sci. 2017; 7 (2) :162-171
URL: http://journal.fums.ac.ir/article-1-1152-en.html
Volume 7, Number 2 (Summer 2017) Back to browse issues page
Journal of Fasa University of Medical Sciences
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