Volume 6, Issue 4 (12-2016)                   JABS 2016, 6(4): 522-529 | Back to browse issues page

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Berenjeian Tabrizi H, Mirdar S, Moghanibashi M M, Ansari Pirsaraei Z. The Effect of High-Intensity Interval Training on Mitochondrial Biogenesis of Lung Tissue. JABS 2016; 6 (4) :522-529
URL: http://jabs.fums.ac.ir/article-1-1211-en.html
1- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran,Iran , hberenjeian@gmail.com
2- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran,Iran
3- School of Medicine, Department of Genetic, Kazerun Branch, Islamic Azad University, Kazerun, Iran
4- Department of Animal Science, Sari Agricultural Sciences and Natural Resources University, Sari, Iran
Abstract:   (9562 Views)

Background & Objectives: It is well established that High-intensity Interval Training (HIT) may represent a time-efficient strategy to induce adaptations normally associated with endurance training. However, the effect of exercise on lung mitochondrial changes is not well understood.The purpose of the present study is to determine the effects of HIT on NRF-1 and PGC-1α genes at mRNA level in rat lung tissue.

Materials & Methods: Twenty Wistar male rats (4 weeks old, 68±9 g weight) were randomly assigned to 6-week training, 9-week training, 6-week control and 9-week control groups. High-intensity interval training program was started with 25 m/min and gradually reached to 70 m/min at the end of the ninth week. Following tissue sampling, RNA extraction and cDNA synthesis, and the expressions of genes were determined by real time RT-PCR technique.

Results: NRF-1 and PGC-1α genes expression were increased following interval training. The expression of NRF-1 and PGC-1α between 9-week training and 9-week control groups was significantly different (P≤0.05).

Conclusion: According to the current study, it seems that intense interval training can cause changes in the mitochondrial content and the possibly of mitochondrial biogenesis in lung tissue.

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Type of Study: Research | Subject: pulmonologist
Received: 2016/08/24 | Accepted: 2016/10/26 | Published: 2017/02/15

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