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:: Volume 8, Issue 1 (Spring 2018) ::
J Fasa Univ Med Sci 2018, 8(1): 582-593 Back to browse issues page
Roles of Integrin and Its Application for Anti-viral Drug Development
Mohammad Hadi Karbalaie Niya 1 , Ahmad Tavakoli 2 , Behrouz Foroughi-Nia 3 , Fahimeh Safarnezhad Tameshkel 4 , Maryam Esghaei 2
1- Research center of pediatric infectious diseases, Institute of immunology and infectious diseases, Iran University of Medical Sciences, Tehran, Iran.Research center of immunology, Institute of immunology and infectious diseases, Iran University of Medical Sciences, Tehran, Iran
2- Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
3- Faculty of Medicine, Dezful University of Medical Sciences, Khozestan, Iran
4- Gastrointestinal & Liver Disease Research Center (GILDRC), Firuzgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Abstract:   (975 Views)

Integrins are a large family of adhesion molecules under cellular control that could act bilabially in different situations; on the other hand, they play a significant role in adsorption and entry of immune system cells or other helper cells. Furthermore, they could be good targets for entry, localization and replication of infectious viruses into cells. As viruses apply various strategies for entry and infiltration to cells, comparison of these ways (especially integrin mediated), elucidates effective mechanisms in the inception of viral infection and the host cells interactions. At this point, the present study reviewed the relationships between common viruses such as Adenovirus, Papillomavirus, Herpesvirus, Hantavirus, Rotavirus, Echovirus, foot-and-mouth disease virus, Coxsackievirus type 9, Parechovirus type 1 and Human immunodeficiency virus type 1 with integrins and their viable interactions for therapeutical issues and better recognition of the commencement process of the infection by these viruses.

Keywords: Integrin, Virus, Receptor, Anti-viral Drug
Full-Text [PDF 938 kb]   (261 Downloads)    
Type of Study: Review | Subject: Virology
Received: 2017/03/1 | Accepted: 2017/10/25 | Published: 2018/06/19
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Karbalaie Niya M H, Tavakoli A, Foroughi-Nia B, Safarnezhad Tameshkel F, Esghaei M. Roles of Integrin and Its Application for Anti-viral Drug Development . J Fasa Univ Med Sci. 2018; 8 (1) :582-593
URL: http://journal.fums.ac.ir/article-1-1237-en.html


Volume 8, Issue 1 (Spring 2018) Back to browse issues page
Journal of Fasa University of Medical Sciences
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