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:: Volume 7, Issue 3 ( Autumn 2017) ::
J Fasa Univ Med Sci 2017, 7(3): 406-415 Back to browse issues page
The comparison of the effect of vitamin E on the expression of p53/PTEN of prostate gland of male rats in two groups of intensive continuous and intermittent exercise training
Amin Allah Dashtiyan 1, Mohammad Esmaeil Afzalpour 2, Nader Tanideh 3, Masood Sepehrimanesh 4
1- Department of Exercise Physiology, University of Birjand, Birjand, Iran , amin.dashtiyan@gmail.com
2- Department of Exercise Physiology, University of Birjand, Birjand, Iran
3- Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4- Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
Abstract:   (1295 Views)

Background & Objective: Physical activity and diet are the most important modifiable determinants of cancer risk. The aim of this study was to investigate the comparison of the effect of vitamin E on the expression of p53/PTEN prostate gland of male rats in two groups of intensive continuous and intermittent exercise training.
Materials & Methods: For this purpose, 56 male rats were randomly divided into 7 groups: [1] control group, [2] sham group, [3] intensive continuous training, [4] intensive intermittent training, [5] intensive continuous training + vitamin E, [6] intensive intermittent training + vitamin E, [7] vitamin E. The research training protocols were conducted in compliance with the principle of overload on the treadmill for six days a week, lasting 6 weeks. To measure expression changes of p53 and PTEN genes in rats' prostate, real-time PCR method was used and HPLC method was used to measure vitamin E. The One-way analysis of Variance test was used for comparisons among groups.
Results: Vitamin E in combination with continuous training induced a significant decrease in the p53 gene expression of IIT + VE group (p > 0/004) compared to the control group. In contrast, vitamin E in combination with intermittent training induced a significant decrease in expression of p53 (p>0/013) and a significant increase in the PTEN gene expression (p>0/035).
Conclusion: The results showed that physical exercise training reduced PTEN and p53 tumor suppressing gene expression by reducing oxidative stress, and vitamin E can be a somewhat increased expression of these genes.
 

Keywords: Vitamin E, Continuous training, intermittent training, p53, PTEN, Prostate Gland
Full-Text [PDF 1056 kb]   (441 Downloads)    
Type of Study: Research | Subject: Cellular-Molecular Biology
Received: 2017/01/12 | Accepted: 2017/07/25 | Published: 2017/12/3
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Dashtiyan A A, Afzalpour M E, Tanideh N, Sepehrimanesh M. The comparison of the effect of vitamin E on the expression of p53/PTEN of prostate gland of male rats in two groups of intensive continuous and intermittent exercise training. J Fasa Univ Med Sci. 2017; 7 (3) :406-415
URL: http://journal.fums.ac.ir/article-1-1325-en.html


Volume 7, Issue 3 ( Autumn 2017) Back to browse issues page
Journal of Fasa University of Medical Sciences
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