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:: Volume 3, Issue 4 (Winter 2014) ::
J Fasa Univ Med Sci 2014, 3(4): 387-391 Back to browse issues page
Polycystic Ovary Induction in Mouse by Testosterone Enanthate
Zahra Kalhori1, Mehri Azadbakht 2, Ali Bazdar1, Hadis Zeinali
1- Razi Universuty
2- , azadbakhtm_tmu@yahoo.com
Abstract:   (12864 Views)
Background &Objective: Polycystic ovary is the most common cause of infertility in Women. Animal models are required for understanding the pathogenesis of polycystic ovary. The objective of this study then was to develop an animal model for inducing the polycystic ovaries using testosterone enanthate.
Materials & Methods: In this study, for inducing the polycystic ovary phenotype, female rats about12-14 days-old were injected daily with testosterone enanthate for 2 and 4 weeks (experiment groups: 1 and 2), while the control groups (1 and 2) were injected only with vehicle.The ovaries from both groups were fixed and then were used for histological studies.
Results: Testosterone enanthate treatment causes the histological changes in mouse ovary and significantly increased the percentage of preantral and cystic follicles and decreased the percentage of antral follicles in the experiment group, comparing with the control group (P<0.05).
Conclusion: It concluded that testosterone enanthate can induces polycystic ovary in mouse.
Keywords: Testosterone enanthate, Polycystic Ovary, Mouse
Full-Text [PDF 847 kb]   (4079 Downloads)    
Type of Study: Research | Subject: Gynecology & Obstetrics
Received: 2012/07/10 | Accepted: 2013/11/3 | Published: 2014/03/16
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Kalhori Z, Azadbakht M, Bazdar A, Zeinali H. Polycystic Ovary Induction in Mouse by Testosterone Enanthate. J Fasa Univ Med Sci. 2014; 3 (4) :387-391
URL: http://journal.fums.ac.ir/article-1-137-en.html

Volume 3, Issue 4 (Winter 2014) Back to browse issues page
Journal of Fasa University of Medical Sciences
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