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:: Volume 8, Issue 1 (Spring 2018) ::
J Fasa Univ Med Sci 2018, 8(1): 657-665 Back to browse issues page
Investigating the Effects of All-trans Retinoic Acid on Histopathology of Pancreas of streptozotocin -Induced Diabetes in C57BL/6 mice
Farin Malekifard 1 , Nowruz Delirezh 2, Rahim Hobbnaghi 3 , Hasan Malekinejad 4
1- Department of Microbiology, Facutly of Veterinary Medicine, Urmia University, Urmia, Iran
2- Department of Microbiology, Facutly of Veterinary Medicine, Urmia University, Urmia, Iran , n.delirezh@urmia.ac.ir
3- Department of Pathobiology, Facutly of Veterinary Medicine, Urmia University, Urmia, Iran
4- Department of Pharmacology, University of Medical Sciences, Urmia, Iran
Abstract:   (287 Views)

Backgrounds & Objectives: Type 1 diabetes is an auto-immune disease and caused by insufficient insulin production by the body. All-trans Retinoic Acid (ATRA) is an antioxidant, anti-cancer and anti-inflammatory agent. The objective of the present study was to investigate the effects of ATRA on histopathology of pancreas in diabetic mice.
Material & Methods: Diabetes was induced by multiple low-dose of streptozotocin injection (40 mg/kg/day for 5 consecutive days) in male C57BL/6 mice. After induction of diabetes, mice were treated with ATRA (20 mg/kg/day i.p.) for 21 days. On the last day, pancreases were isolated and stained with hematoxylin &eosin (H&E) and Gomeri aldehyde fuchsin (GAF) for histological analyses (the number of islets and β cells, diameter of islets) of pancreas.
Results: ATRA treatment in streptozotocin-induced diabetic mice was increased the mean diameter of islets and the number of islets and beta cells compared to the diabetic group. (p<0/05).
Conclusion: The administration of ATRA improved pancreas tissue during destruction of the pancreatic beta-cells in STZ-induced type 1 diabetes in mice.
 

Keywords: Type 1 diabetes, All-trans Retinoic Acid, Pancrease, Streptozotocin
Full-Text [PDF 999 kb]   (92 Downloads)    
Type of Study: Research | Subject: Immunology
Received: 2017/04/30 | Accepted: 2017/12/9 | Published: 2018/05/30
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Malekifard F, Delirezh N, Hobbnaghi R, Malekinejad H. Investigating the Effects of All-trans Retinoic Acid on Histopathology of Pancreas of streptozotocin -Induced Diabetes in C57BL/6 mice. J Fasa Univ Med Sci. 2018; 8 (1) :657-665
URL: http://journal.fums.ac.ir/article-1-1430-en.html


Volume 8, Issue 1 (Spring 2018) Back to browse issues page
Journal of Fasa University of Medical Sciences
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