[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Submit :: Contact Us ::
:: Volume 8, Issue 4 (Winter 2019) ::
J Fasa Univ Med Sci 2019, 8(4): 1127-1135 Back to browse issues page
The Comparison between the Effect of Moderate & prolonged Swimming Training on Liver Tissue LXRα Gene Expression & Serum Cholesterol and Triglyceride levels in Male Wistar Rats
Leila Vesali-akbarpoor1 , Mohammad Ali Samavati Sharif 2, Sima Mirzayi1 , Parivash Piraki3
1- Department of Exercise Physiology, Faculty Sport Sciences, Bu-Ali Sina University, Hamadan, Iran
2- Department of Exercise Physiology, Faculty Sport Sciences, Bu-Ali Sina University, Hamadan, Iran , m-samavati@basu.ac.ir
3- Department of Exercise Physiology, Islamic Azad University Darre Shahr Branch, Borujerd, Iran
Abstract:   (1165 Views)
Background & Objectives: Liver X-Alpha Receiver is a family of large hormone receptors that play a role in cholesterol homeostasis. The purpose of the present study was to investigate the effect of ten weeks of moderate and long term endurance exercise on the expression of the LXRα gene and the evaluation of serum levels of cholesterol and triglyceride in male rats.
Materials & Methods: 18 male Wistar rats were randomly divided in to three groups of six, control, moderate and long swimming, in the range of 275±25g. The training groups swam in 32 degrees water for ten weeks and 5 days a week. The moderate group swam for one hour and a long group each session for three hours. After the completion of the exercise, blood sampling from the underlying vena-cava and tissue from the rat liver was performed. Real-time PCR was used to measure the of LXRα gene expression by Ampliqon mixer and DNA synthesis kits. Differences were determined by ANOVA One-Way method and the groups were compared by Tukey follow-up test. Pearson correlation was used to determine the correlation between levels of expression of LXRα gene with cholesterol and triglyceride. SPSS software version20 was used at the significance level of p≤0.05.
Results: The moderate exercise group showed a significant increase in LXRα gene and a significant reduction in cholesterol and triglyceride compared to both control and prolonged groups (p=0.001). Also, LXRα gene expression in this group had a negative and significant correlation with cholesterol (rs=-0.912) and triglyceride (rs=-0.862).
Conclusion: It seems that the positive mechanism induced by moderate swelling by increasing the expression of the LXRα gene results in the release of cell lipid makers.
 
 
Keywords: Endurance swimming training, LXRα gene, Cholesterol, Triglyceride
Full-Text [PDF 1130 kb]   (185 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2018/02/6 | Accepted: 2018/08/6 | Published: 2019/03/17
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Vesali-akbarpoor L, Samavati Sharif M A, Mirzayi S, Piraki P. The Comparison between the Effect of Moderate & prolonged Swimming Training on Liver Tissue LXRα Gene Expression & Serum Cholesterol and Triglyceride levels in Male Wistar Rats . J Fasa Univ Med Sci. 2019; 8 (4) :1127-1135
URL: http://journal.fums.ac.ir/article-1-1583-en.html


Volume 8, Issue 4 (Winter 2019) Back to browse issues page
Journal of Fasa University of Medical Sciences
Persian site map - English site map - Created in 0.07 seconds with 32 queries by YEKTAWEB 3921