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:: Volume 8, Issue 4 (Winter 2019) ::
J Fasa Univ Med Sci 2019, 8(4): 1136-1145 Back to browse issues page
Effect of Fasciola hepatica on acetic acid induced ulcerative colitis in rat model
Bijan Esmaeilnejad 1, Meysam Abtahi fouroshani , Ali Asghar Tehrani2 , Hadi Esmaeili govarchin galeh3 , Farshid Moshrefzadeh2
1- Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran , meysamabtahi@hotmail.com
2- Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
3- Applied Virology Research Center, Baqiyatallah University of Medical Science, Tehran, Iran
Abstract:   (1418 Views)
Background & Objective: Ulcerative colitis is one of the common causes of gastrointestinal tract diseases in developing countries. This disease causes disability, especially in young adults, and imposes many social and economic burdens on the community. The aim of this study was to investigate the effects Effect of Fasciola hepatica extract on acetic acid induced ulcerative colitis in rat model.
Materials & Methods: Thirty adult male Wistar rats were divided into 3 equal groups. Colitis was induced by administration of 4% acetic acid. Control group just was administrated phosphate-bufferedsaline (S.C.) and the other groups were received Prednisolone (0.5 mg/kg) and Fasciola hepatica extract (100 mg/kg) for 10 consecutive days.Since then, the animals were euthanized and intestinal tissue and blood samples were taken. Macroscopic and microscopic features, inflammatory mediators as well as cytokines, TNF-α and IL-6 were assessed.
Results: The amount of the myeloperoxidase production was the same between the two treatment groups. As compared to the control, both of the treatment groups produced lower amount of TNF-α and IL-6, however this reduction was more pronounced in Prednisolone treated animals than those of extract treated. There were no significant differences between Prednisolone andFasciola extract regarding gross damages and histopathological features.
Conclusion: since preparation of Fasciola extract is easy and simple, it may be used as ameliorative agent for ulcerative colitis.
 
 
Keywords: Ulcerative colitis, Acetic acid, Rat, Fasciola hepatica, inflammation
Full-Text [PDF 1086 kb]   (210 Downloads)    
Type of Study: Research | Subject: Immunology
Received: 2018/02/7 | Accepted: 2018/08/6 | Published: 2019/03/17
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Esmaeilnejad B, abtahi fouroshani M, Tehrani A A, esmaeili govarchin galeh H, moshrefzadeh F. Effect of Fasciola hepatica on acetic acid induced ulcerative colitis in rat model . J Fasa Univ Med Sci. 2019; 8 (4) :1136-1145
URL: http://journal.fums.ac.ir/article-1-1584-en.html


Volume 8, Issue 4 (Winter 2019) Back to browse issues page
Journal of Fasa University of Medical Sciences
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