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:: Volume 8, Issue 3 ( Autumn 2018) ::
J Fasa Univ Med Sci 2018, 8(3): 854-861 Back to browse issues page
Synthesis of Zataria Multiflora extraction loaded chitosan/PEO nanofibers via electrospinning method for potential biomedical applications
Elham Karimi 1, Minoo Sadri2 , Motahare Hosseini3 , Ali Heidari3 , Samane Kargar-ghalesefi3 , Zeinab Krimimoghadam4
1- Nutrition and Food Safety Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran , elham939k@gmail.com
2- Biological Science and Technology Research Center, Malek Ashtar University of Technology, Tehran, Iran
3- . Zoonotic Diseases Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4- Fasa University of Medical Sciences, Fasa, Iran
Abstract:   (2314 Views)
Background & Objective: The nanofibers are referred to as fibers with a diameter of less than 1000 nm. There are various ways to make nanofibers, one of which is electrospinning. In this method, nanofibers are formed on aluminum sheets. The conversion of chitosan to derivatives with greater solubility, its mixing with other polymers and the use of special solvents are methods for its ease of use. In this study, antimicrobial thyme extracts were prepared for the synthesis of chitosan / polyethylenoxide and thyme nanofibers by electroporation.
Materials & methods: Using electrospinning, chitosan and polyethylenoxide were prepared Ratio of 90 to 10 and 80% tween in a 0.5 molar acetic acid solution. Thyme extract was added and after the synthesis of nanofibers, images of SEM were taken, then the diameter of the nanofibers with clemex vision software was measured.
Results: According to the scanning electron microscopy (SEM) images and the nanofibers diameter obtained from the solution with chitosan / polyethylenoxide / thyme formulation with Ratio of 90 to 10, the mean diameter of nanofibers was in the range of 100-60 nm (best fiber with the lowest node).
Conclusion: Prepared nanofibers are widely used in the medical industry, especially in the field of tissue engineering and wound scaffolds and also are used as antibacterial candidate. In addition to being effective in wound healing, they also reduce the cost of treatment.
Keywords: Chitosan, Polyethylenoxide, Nanofiber, Electrospinning, SEM
Full-Text [PDF 959 kb]   (445 Downloads)    
Type of Study: Research | Subject: Nanomedicine
Received: 2017/12/11 | Accepted: 2018/07/7 | Published: 2018/12/22
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karimi E, sadri M, hosseini M, heidari A, kargar-ghalesefi S, Krimimoghadam Z. Synthesis of Zataria Multiflora extraction loaded chitosan/PEO nanofibers via electrospinning method for potential biomedical applications. J Fasa Univ Med Sci. 2018; 8 (3) :854-861
URL: http://journal.fums.ac.ir/article-1-1618-en.html


Volume 8, Issue 3 ( Autumn 2018) Back to browse issues page
Journal of Fasa University of Medical Sciences
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