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:: Volume 8, Issue 4 (Winter 2019) ::
J Fasa Univ Med Sci 2019, 8(4): 1068-1078 Back to browse issues page
Effects of 4 week endurance training on PGC-1α expression in adipose tissue, ANGPTL8 serum concentrations and beta cells function of STZ diabetic rats
Hamid Reza Sadeghipour 1, Mohsen Salesi2 , Alireza Rabiezade3
1- Department of Physical Education, Persian Gulf University, Bushehr, Iran , h.rsadeghi@yahoo.com
2- Faculty of Psychology and Education University, Shiraz, Iran, Shiraz
3- Department of Physical Education, Persian Gulf University, Bushehr, Iran
Abstract:   (1470 Views)
Background & Objective: Angiopoietin-like Proteins 8 (ANGPTL8) which secreted form adipose tissue due to downstream PGC-1α pathways, is the main factor for regeneration of beta cell. The aim of this study was to investigate the effect of 4 endurance training program on PGC-1α expression in adipose tissue, ANGPTL8 serum concentration and beta cell function (HOMA.B) in diabetic rats.
Materials & methods: Male Wistar rats (N=24) divided in 3 groups include healthy control (HC), diabetic control (DC) and endurance training (ET). After induction of diabetes with STZ, training groups performed 4 weeks endurance training and real-time polymerase chain reaction (Real-Time PCR) method used for the relative expression of PGC-1α in visceral adipose tissue, the enzyme-linked immunosorbent assay (ELISA) method for measuring serum ANGPTL8 levels. Also beta cell number was counted with pancreases hematoxylin-eosin evaluation. Results analyzed with ANOVA.
Results: The relative expression of mRNA PGC-1α was significantly increased in ET (P=0.001). Although ANGPTL8 levels increased in ET group, this change wasn’t significant (P=0.47). HOMA.B didn’t showed any significant change in ET (P=.0.08) but the number of beta cells in this group significantly increased (P=0.001). There was a positive correlation between relative mRNA PGC-1α and ANGPTL8 levels.
Conclusion: Despite the positive and significant correlation between relative expression of mRNA PGC-1α and ANGPTL8, this increase wasn’t significant, but this could increases the number of beta cell in endurance training group. Further studies with differences training programs are recommended.
 
Keywords: Endurance Training, Beta Cells proliferation, PGC-1α, ANGPTL8
Full-Text [PDF 1041 kb]   (211 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2018/02/24 | Accepted: 2018/06/12 | Published: 2019/03/17
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Sadeghipour H R, Salesi M, Rabiezade A. Effects of 4 week endurance training on PGC-1α expression in adipose tissue, ANGPTL8 serum concentrations and beta cells function of STZ diabetic rats. J Fasa Univ Med Sci. 2019; 8 (4) :1068-1078
URL: http://journal.fums.ac.ir/article-1-1635-en.html


Volume 8, Issue 4 (Winter 2019) Back to browse issues page
Journal of Fasa University of Medical Sciences
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