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:: Volume 9, Issue 2 (summer 2019) ::
J Fasa Univ Med Sci 2019, 9(2): 1425-1432 Back to browse issues page
The Effect of Eight Weeks of Curcumin Supplementation on the Expression of Some Regulatory Genes of Atrophic Processes in the Heart Tissue of Fatty Adult Fatty Rats
Atefeh Raoufi1 , Farsi Sirous 2, Ali Hoseini3
1- Department of exercises Physiology, Islamic Azad University, Larestan Branch, Larestan, Iran
2- Department of exercises Physiology, Islamic Azad University, Larestan Branch, Larestan, Iran , Sirous.farsi@gmail.com
3- Department of exercises Physiology, Islamic Azad University, Marvdasht Branch, Marvdasht , Iran
Abstract:   (246 Views)

Background & Objective: Obesity causes heart muscle atrophy. The purpose of this study was to investigate the effect of curcumin supplement on expression of PGC1α, FoxO3a, MuRF1, MAFbx as regulators of cardiac muscle atrophy of rats.
Material and Methods: 12 male Sprague Dawley rats were divided into two groups: obese (n = 6) and curcumin supplement (n = 6) after eight weeks of using high fat diet. The rats received curcumin for eight weeks and 150 mg / kg daily. The expression of genes was performed using Real Time-PCR technique. The expression of genes was calculated using the 2-∆∆CTmethod. One-way ANOVA was used to determine the significance of the variables among the study groups.
Results: The administration of curcumin resulted in a significant reduction in the expression of genes of FoxO3a (P = 0.008), MAFbx (P = 0.02), MuRF1 (P = 0.001), and a significant increase in PGC1α gene expression (P = 0.004).
Conclusion: Probably, administration of curcumin can be used to suppress heart muscle atrophy due to obesity by controlling the muscle atrophy pathway.
 

 
Keywords: Obesity, Curcumin, Heart Diseases, Polyphenols
Full-Text [PDF 622 kb]   (27 Downloads)    
Type of Study: Research | Subject: Cellular-Molecular Biology
Received: 2018/12/4 | Accepted: 2019/05/7 | Published: 2019/09/18
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Raoufi A, sirous F, Hoseini A. The Effect of Eight Weeks of Curcumin Supplementation on the Expression of Some Regulatory Genes of Atrophic Processes in the Heart Tissue of Fatty Adult Fatty Rats. J Fasa Univ Med Sci. 2019; 9 (2) :1425-1432
URL: http://journal.fums.ac.ir/article-1-1896-en.html


Volume 9, Issue 2 (summer 2019) Back to browse issues page
Journal of Fasa University of Medical Sciences
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