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Evaluation of Relationship between Blood Concentration of Vitamin D and Ejection Fraction, Homocysteine, Calcium and CRP in Bushehr Heart Center
Dariush Iranpour1 , Saba Bahremandjou2 , Niloufar Motamed3 , Najmeh Hajian4 , Rahimeh Rahimi4 , Ali Movahed 5
1- Department of Cardiology, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
2- Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
3- Department of Community Medicine, Faculty of Medicine, Bushehr University of Medical Sciences, Moallem Street, Bushehr, Iran
4- Department of Biochemistry, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
5- The Persian Gulf Tropical Medicine Research Center, Departments of Biochemistry, Bushehr University of Medical Sciences, Bushehr, Iran , amovahed58@gmail.com
Abstract:   (146 Views)
Background & Objective: The aim of this study was to evaluate the association between blood concentration of vitamin D and cardiovascular diseases, with regard to the percentage of ejection fraction, the number of coronary artery blockage, concentration of homocysteine, CRP and Ca.
Materials & Methods: In this case-controlled investigation, 433 people who referred to Bushehr Heart Center for medical examination participated. Based on the preliminary results of clinical tests including ECG, echocardiogram, and angiography, the participants were selected and divided into case and control groups. Venous blood samples were collected (10 ccs) and immediately centrifuged and the serum samples were separated and stored at -80 ᵒC until analysis. The ejection fraction was recorded and the serum samples were processed for the measurement of 25-hydroxyvitamin D, homocysteine, calcium and CRP concentration.
Results: The mean concentration of vitamin D in the serum of case group was significantly lower than that of the control. Moreover, the mean percentage of EF in the control group was significantly higher than that of the control group. Furthermore, the serum level of vitamin D and the atherosclerosis of coronary arteries were inversely correlated. Moreover, the mean concentration of CRP was significantly higher in the case group than in the control gorup.
Conclusion: The result of this study showed that low serum levels of vitamin D may be related to cardiovascular disease. Moreover, vitamin D levels were inversely associated with the number of atherosclerotic arteries in men only.
 
Keywords: vitamin D, Ejection fraction, Coronary Atherosclerosis, coronary artery disease
     
Type of Study: Research | Subject: Biochemistry
Received: 2018/12/24 | Accepted: 2019/08/17
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