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The Role of Gut Microbiome in Initiation of Inflammatory Bowel Disease; A Review
Taher Azimi1 , Hossein Dabiri 2, Sahar Sabour3 , Aref Shariati4 , Javad Yasbolaghi5 , Hossein Dabiri5
1- Department of Pathobiology, Faculty of Health, Tehran University of Medical Science, Tehran, Iran
2- Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran , H.dabiri@hotmail.com
3- Department of Microbiology, Faculty of Medicine, Ardabil University of Medical Science, Ardabil, Iran
4- Department of Microbiology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran
5- . Department of Microbiology, Faculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
Abstract:   (171 Views)
 Inflammatory bowel disease (IBD) is a prolonged and disabling functional gastrointestinal disorder with the incidence rate of more than 0.5% in public individuals, worldwide. IBD including Ulcerative colitis (UC) and Crohn’s disease (CD) need to be taken into account that it is a heterogeneous illness which can take place by the convergence of host immune system disorders, genetic and environmental factors, gut microbiota dysbiosis, and can progress in people who are genetically susceptible. Overexposure of immune system to the excessive bacterial substances can also lead to the loss of immunological tolerance to bacteria, which are considered as normal flora in the body of the host which may subsequently result in bowel inflammation and IBD development. Generally, the role of infections in the initiation and development of inflammatory disease of the gastrointestinal tract has been studied by many clinical findings and it has been proved that gut microbiome via several mechanisms plays a significant role in initiation and exacerbation of IBD. It appears that the most important pathogens which correspond with the IBD include Helicobacter pylori, Clostridium difficile, Escherichia coli, Listeria monocytogenes, Campylobacter concisus as well as viruses such as Cytomegalovirus, Epstein Barr and Rubella. Based on the current knowledge, the current study discusses the most common pathogens that may be involved in the development of IBD and performs a comprehensive review on related evidence supporting or ignoring the possible role of microorganisms.
Keywords: Inflammatory bowel disease, intestinal pathogens, gut bacterium
Type of Study: Review | Subject: Infectious disease
Received: 2018/12/30 | Accepted: 2019/08/6
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