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Effects of combined exercise (aerobic + resistance) on the expression of miR-301a and some indicators of motor function in women with multiple sclerosis (MS)
Saman Yousefi saggezi1 , Akbar Azamian Jazi 2, Roohullah Hemmati3 , Nahid Jivad4
1- Department of Sports Science, Shahrekord University, ShahreKord, Iran
2- Department of Sports Science, Shahrekord University, ShahreKord, Iran , Azamianakakbar@yahoo.com
3- Department of Biology, Faculty of basic science, Shahrekord University, ShahreKord, Iran
4- Department of Neurology, Shahrekord University of Medical Sciences, ShahreKord, Iran
Abstract:   (140 Views)
Background & Objective: Several evidence has indicated the effective role of exercise on Multiple sclerosis (MS) patients. An aberrant expression of some Micro-RNAs such as increasing miR-301a in MS, with an impact on inflammatory pathways leading to the creation of inflammation in these patients. The purpose of this study was to investigate the effect of a combined eight-week (aerobic and resistance) exercise on expression of miR -301a and some indicators of motor function in women with multiple sclerosis.
Materials & Methods: A total of 22 women with MS, who were randomly divided into experimental and control groups, participated in this study. The experimental group performed 8 weeks (4 days per week) of combined training. Expression of miR -301a was measured before and after the training period using Real-Time PCR method. Pre- and post-intervention scores of tests (TUG), (6MWT), (10–MWT) and status scale (EDSS) were independent t-test recorded and analyzed.
Results: The results of this study showed, the expression of miR -301a was significantly different between the two groups (P = 0.001). Tests TUG (P = 0.001), 6MWT (P = 0.002) and degree of disability EDSS (P = 0.015), were significantly different between the two groups. There was no significant difference between the 10MWT test between the two group (P = 0.678).
Conclusion: The combined exercise for women with MS have been beneficial and improve motor function and reduce the expression of miR-301a. So, do it, plays an important role in reducing inflammation and prevent the progression of the disease Ms.
 
 
Keywords: MS, combined exercise, miR -301a, Motor function, EDSS
     
Type of Study: Research | Subject: Immunology
Received: 2019/01/6 | Accepted: 2019/03/12
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