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Volume 10, Issue 1 (4-2020)
JABS 2020, 10(1): 1998-2011 |
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Javadi A, farzaneh M, Mokhtar S, Azimirad R, Esfandiari F, Gourabi H. Mechanisms of the Effects of Zinc Oxide Nanostructures on Living Cells. JABS 2020; 10 (1) :1998-2011
URL: http://jabs.fums.ac.ir/article-1-2037-en.html
URL: http://jabs.fums.ac.ir/article-1-2037-en.html
Azam Javadi1 
, Maryam Farzaneh2 , Saadati Mokhtar3 , Rohollah Azimirad4 , Fereshteh Esfandiari5 , Hamid Gourabi * 6
, Maryam Farzaneh2 , Saadati Mokhtar3 , Rohollah Azimirad4 , Fereshteh Esfandiari5 , Hamid Gourabi * 6
1- Department of Genetic, Faculty of Basic Science and Advanced Technologies, University of Science and Culture, Royan Institute, Tehran, Iran
2- Department of Cell & Molecular Biology, Faculty of basic science and advanced technologies, University of Science and Culture, Royan Institute, Tehran, Iran
3- Department of Physics, Shahid Beheshti University, Tehran, Iran
4- Department of Physics, Sharif University of Technology, Tehran, Iran
5- Department of Cell & Molecular Biology, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
6- Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran ,gourabi@royaninstitute.org
2- Department of Cell & Molecular Biology, Faculty of basic science and advanced technologies, University of Science and Culture, Royan Institute, Tehran, Iran
3- Department of Physics, Shahid Beheshti University, Tehran, Iran
4- Department of Physics, Sharif University of Technology, Tehran, Iran
5- Department of Cell & Molecular Biology, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
6- Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran ,
Abstract: (3148 Views)
Nowadays, nanotechnology and nanostructures, which are particles smaller than 100 nm in size at least in one dimension, are being widely used in various industries and consumer products, biomedical applications and environments. Unique properties of Zinc oxide (ZnO) nanostructures offer technological advantages for a variety of industrial and consumer products as well as show promise for biomedical application. They are used as an antibacterial agent in food packaging, such as UV absorbent in cosmetics and sunscreens. However, high concentrations of ZnO nanostructures have toxic effects on living organisms. The toxic effect of these nanostructures depends on target cell type, size, structure, and surface properties of nanostructures, as well as exposure routes. In this article, we discuss the toxic effect of ZnO nanostructures and different mechanisms including ROS production and the resulting oxidative stress, genomic toxicity, changes in gene expression and following protein production, epigenetic changes and inflammatory responses and apoptosis. Also, we will mention many in vivo studies about this nanoparticle.
Type of Study: Review |
Subject:
Nanomedicine
Received: 2019/05/26 | Accepted: 2019/10/20 | Published: 2020/02/27
Received: 2019/05/26 | Accepted: 2019/10/20 | Published: 2020/02/27
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This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)