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:: Volume 9, Issue 4 (Winter 2019) ::
J Fasa Univ Med Sci 2019, 9(4): 1682-1692 Back to browse issues page
The Role of Biomarkers in Diagnosis, Prognosis, Treatment, Determining Disease Activity in Rheumatoid Arthritis
Mahsa Saffar1 , Hiva Alipanah2 , Mohammad Reza Ataollahi 3
1- Student ResearchCommittee, Fasa University of Medical Science, Fasa, Iran
2- Department of Physiology, Faculty of Medicine, Fasa University of Medical Science, Fasa, Iran
3- Department of Immunology, Faculty of Medicine, Fasa University of Medical Science, Fasa, Iran , ataollahimr@gmail.com
Abstract:   (1256 Views)
Rheumatoid arthritis (RA) is a chronic inflammatory and complex autoimmune disease. It affects mainly small joints (of the hands and feet) and has many systemic manifestations.
The study of biomarkers in rheumatology is important to understand the mechanism involved in some rheumatic diseases. Discovering new biomarkers with key roles in various stages of the disease remains as an important issue in RA patients. Biomarkers are important for diagnosis and prognosis, target therapy, and guiding the clinical and response treatment of all phases of RA. Biomarkers improve diagnosis by closing the serological gap, providing prognostic information that allows disease activity and progression to be monitored. Biomarkers can be correlated with a risk of developing RA and can predict bone erosions and disease progression. Therefore, there is a need for a sensitive biomarker for early diagnosis of the disease. Some biomarkers are not specific (Rheumatoid Factor IgM) and some are not widely used due to technical problems (Antiprenuclear factor). On the other hand, anti-cyclic citrullinated peptide (anti-CCP) in the serum of patients are more specific for these patients.This move from traditional approaches to use more specific biomarkers for patient stratification and targeted treatment should greatly improve patient care and reduce medical costs.
 
 
 
Keywords: Rheumatoid arthritis, Biomarker, Diagnosis, Prognosis, disease activity
Full-Text [PDF 1069 kb]   (226 Downloads)    
Type of Study: Review | Subject: Immunology
Received: 2019/10/4 | Accepted: 2019/11/5 | Published: 2020/03/15
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saffar M, Alipanah H, Ataollahi M R. The Role of Biomarkers in Diagnosis, Prognosis, Treatment, Determining Disease Activity in Rheumatoid Arthritis. J Fasa Univ Med Sci. 2019; 9 (4) :1682-1692
URL: http://journal.fums.ac.ir/article-1-2141-en.html


Volume 9, Issue 4 (Winter 2019) Back to browse issues page
Journal of Fasa University of Medical Sciences
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