Journal of Advanced Biomedical Sciences
JABS
Sun, May 5, 2024
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Volume 13, Issue 2 (5-2023)
JABS 2023, 13(2): 138-147 |
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Ghane F, Rasouli P, Khanjari B, Yousofi A, Zarenezhad A, Fattahi H, et al . Antimicrobial Activity and Wound Healing Properties of Aloe Arborescens Extract: An in Vivo Study. JABS 2023; 13 (2) :138-147
URL: http://jabs.fums.ac.ir/article-1-2950-en.html
URL: http://jabs.fums.ac.ir/article-1-2950-en.html
Fatemeh Ghane1 
, Pegah Rasouli2 , Benafshe Khanjari1 , Alireza Yousofi3 , Ali Zarenezhad4 , Hossein Fattahi5 , Mahsa Rostami Chaijan4 , Abdolmajid Ghasemian4 , Behnoosh Miladpour6 , Elham Zarenezhad * 7
, Pegah Rasouli2 , Benafshe Khanjari1 , Alireza Yousofi3 , Ali Zarenezhad4 , Hossein Fattahi5 , Mahsa Rostami Chaijan4 , Abdolmajid Ghasemian4 , Behnoosh Miladpour6 , Elham Zarenezhad * 7
1- Department of Chemistry, Darab branch, Islamic Azad University, Darab, Iran
2- Department of Chemistry, Fasa branch, Islamic Azad University, Fasa
3- Department of Pathology, Faculty of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran
4- Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
5- Department of Microbiology, Faculty of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran
6- Department of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Iran
7- Noncommunicable Diseases Research Center, Fasa University of MEdical Sciences, Fasa, Iran , el.zarenezhad@gmail.com
2- Department of Chemistry, Fasa branch, Islamic Azad University, Fasa
3- Department of Pathology, Faculty of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran
4- Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
5- Department of Microbiology, Faculty of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran
6- Department of Clinical Biochemistry, Fasa University of Medical Sciences, Fasa, Iran
7- Noncommunicable Diseases Research Center, Fasa University of MEdical Sciences, Fasa, Iran , el.zarenezhad@gmail.com
Abstract: (744 Views)
Background & Objective: Burn is one of the prominent causes of death around the world, however drug discovery attempts for burn healing has not been entirely successful. Aloe arborescens (A. arborescens), is effective in the burning wounds healing and growth inhibition of bacterial pathogens. Our objective was to assess the wound healing and antibacterial effects of A. arborescens in vivo.
Materials & Methods: Thirty healthy Wistar rat animals were enrolled. The treatment process continued for 21 days and sampling was conducted on days 14 and 21 and the tissue slides were sent to the pathology laboratory for testing. The bactericidal activity of A. arborescens extract was evaluated using the disc diffusion method.
Results: A. arborescens demonstrated a significant effect on the healing of burn wounds. Furthermore, the antibacterial effects of the A. arborescens extract against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) was significantly higher than that against Gram-positive (Staphylococcus aureus, Bacillus cereus) bacterial species.
Conclusion: In conclusion, this study indicated that A. arborescens extract had an improving effect on the healing process of third degree burns without toxicity to the tissue.
Materials & Methods: Thirty healthy Wistar rat animals were enrolled. The treatment process continued for 21 days and sampling was conducted on days 14 and 21 and the tissue slides were sent to the pathology laboratory for testing. The bactericidal activity of A. arborescens extract was evaluated using the disc diffusion method.
Results: A. arborescens demonstrated a significant effect on the healing of burn wounds. Furthermore, the antibacterial effects of the A. arborescens extract against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) was significantly higher than that against Gram-positive (Staphylococcus aureus, Bacillus cereus) bacterial species.
Conclusion: In conclusion, this study indicated that A. arborescens extract had an improving effect on the healing process of third degree burns without toxicity to the tissue.
Type of Study: Research |
Subject:
Pathology
Received: 2023/02/19 | Accepted: 2023/05/10 | Published: 2023/07/1
Received: 2023/02/19 | Accepted: 2023/05/10 | Published: 2023/07/1
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This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)