Journal of Advanced Biomedical Sciences
JABS
Thu, May 15, 2025
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Volume 14, Issue 4 (9-2024)
JABS 2024, 14(4): 319-330 |
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Loghmani A, Kamalpour M, Amrollahi-Sharifabadi A M, Bahrami-Tapehbour M. Targeted Nanoparticle Therapy with Betaine-Conjugated Gold Nanoparticles Reduces Inflammation and Makes Immunomodulation in Heatstroke in Mice. JABS 2024; 14 (4) :319-330
URL: http://jabs.fums.ac.ir/article-1-3114-en.html
URL: http://jabs.fums.ac.ir/article-1-3114-en.html
Alireza Loghmani *1 
, Mohammad Kamalpour2 , A Mohammad Amrollahi-Sharifabadi2 , Mohammad Bahrami-Tapehbour3
, Mohammad Kamalpour2 , A Mohammad Amrollahi-Sharifabadi2 , Mohammad Bahrami-Tapehbour3
1- Department Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran , Alirez.loghmani66@gmail.com
2- Department of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran
3- Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran
2- Department of Basic Sciences, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran
3- Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran
Abstract: (601 Views)
Background & Objectives: This study investigates the potential of betaine-conjugated gold nanoparticles (GNPs) as a treatment for inflammation caused by heatstroke. Heatstroke is characterized by elevated body temperature and severe inflammation, which can lead to organ dysfunction. Traditional treatments, such as cooling and supportive care, often fail to prevent long-term damage. GNPs serve as targeted carriers for delivering bioactive agents like betaine to inflamed tissues. The study used a murine model of heatstroke to assess the effects of GNPs, betaine, and their combination on inflammation markers and cellular stress.
Materials & Methods: Mice were divided into groups receiving different treatments, and outcomes such as cytokine levels (TNF-α, IL-6, IL-10), heat shock protein (HSP70) expression, and splenocyte proliferation were measured.
Results: The results demonstrated that the combination of GNPs and betaine notably decreased the amounts of pro-inflammatory cytokines (TNF-α and IL-6) while increasing the levels of the anti-inflammatory cytokine IL-10. The therapy also diminished HSP70 expression, which indicates lowered cellular stress in the GNP-betaine group. Additionally, treatment with GNP-betaine significantly promoted lymphocyte proliferation, indicating an enhancement in immune function under heatstroke conditions.
Conclusion: This study emphasizes the promise of betaine-conjugated GNPs as an innovative therapeutic strategy for reducing inflammation and oxidative stress linked to heatstroke. The results illuminate the collaborative effects of nanotechnology and bioactive substances in addressing inflammatory pathways, presenting a hopeful avenue for managing heat-related inflammatory ailments.
Materials & Methods: Mice were divided into groups receiving different treatments, and outcomes such as cytokine levels (TNF-α, IL-6, IL-10), heat shock protein (HSP70) expression, and splenocyte proliferation were measured.
Results: The results demonstrated that the combination of GNPs and betaine notably decreased the amounts of pro-inflammatory cytokines (TNF-α and IL-6) while increasing the levels of the anti-inflammatory cytokine IL-10. The therapy also diminished HSP70 expression, which indicates lowered cellular stress in the GNP-betaine group. Additionally, treatment with GNP-betaine significantly promoted lymphocyte proliferation, indicating an enhancement in immune function under heatstroke conditions.
Conclusion: This study emphasizes the promise of betaine-conjugated GNPs as an innovative therapeutic strategy for reducing inflammation and oxidative stress linked to heatstroke. The results illuminate the collaborative effects of nanotechnology and bioactive substances in addressing inflammatory pathways, presenting a hopeful avenue for managing heat-related inflammatory ailments.
Type of Study: Research |
Subject:
Immunology
Received: 2024/10/19 | Accepted: 2024/11/25 | Published: 2024/12/21
Received: 2024/10/19 | Accepted: 2024/11/25 | Published: 2024/12/21
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This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)