[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Submit :: Contact Us ::
:: Volume 4, Issue 3 (Autumn 2014) ::
J Fasa Univ Med Sci 2014, 4(3): 344-352 Back to browse issues page
Investigation of curcumin effects on liver tissue in adult male rats treated with cyclophosphamide
Zahra Khodaparast 1, Ali reza Yousofi2, Ameneh Khoshvagti3
1- Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran. , Zahra.khodaparast91@yahoo.com
2- Department of Pathological, School of Veterinary Medicine, kazerun branch, Islamic Azad University, kazerun, Iran.
3- Department of Clinical Sciences, Faculty of Veterinary Medicine, Kazerun branch, Islamic Azad University, Kazerun, Iran.
Abstract:   (10698 Views)
 

Background & Objective: Cyclophosphamide is an antineoplastic drug that has many clinical uses in cancer treatment, but it has toxic effects due to creation of free radicals. In this study, the effects of curcumin" as an antioxidant drug” on liver tissue was investigated.

 

Materials & methods: 50 wistar adult male rats were selected randomly and were divided in to five groups including control, sham (receiving normal saline and olive oil), cyclophosphamide (5 mg/kg intraperitoneal), cyclophosphamide (5 mg/kg) + curcumin (50 mg/kg), and curcumin (50 mg/kg by gavage). This study continued for 30 days. The liver histopathological changes were investigated after the last administration.

 

Results: Severe apoptosis, hepatocytes necrosis, congestion, focal inflammation, and endotheliosis were revealed in cyclophosphamide receiving group. However, focal inflammation and hepatocyte necrosis were decreased considerably in cyclophosphamide + curcumin group compared to cyclophosphamide group. Congestion and endotheliosis were very small. None of the above mentioned complications was observed in curcumin receiving group.

 

Conclusion: The results of this study show the concurrent consumption of cyclophosphamide and curcumin can reduce the cyclophosphamide free radicals effects on liver tissue.

 

 

 
Keywords: Curcumin, Liver, cyclophosphamide, Rat, Pathologic effects
Full-Text [PDF 1509 kb]   (3711 Downloads)    
Type of Study: Research | Subject: Pathology
Received: 2014/06/28 | Accepted: 2014/08/12 | Published: 2014/12/20
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

khodaparast Z, yousofi A R, khoshvagti A. Investigation of curcumin effects on liver tissue in adult male rats treated with cyclophosphamide. J Fasa Univ Med Sci. 2014; 4 (3) :344-352
URL: http://journal.fums.ac.ir/article-1-594-en.html


Volume 4, Issue 3 (Autumn 2014) Back to browse issues page
Journal of Fasa University of Medical Sciences
Persian site map - English site map - Created in 0.06 seconds with 32 queries by YEKTAWEB 3961