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:: Volume 5, Number 2 (Summer 2015) ::
J Fasa Univ Med Sci 2015, 5(2): 269-277 Back to browse issues page
Studying the Frequency of Favorable Allele of rs12979860 Polymorphism of IL-28B in Healthy and HCV Infected Iranian Individuals
Abdolvahab Alborzi1, Tayebeh Hashempour 2, Mahboobe Mirhoseini3, nasim Adim3, Javad Moayedi1, Zahra Musavi1, Shahin Merat4, Gholam Reza Pouladfar1, Mehrdad Hallaji1, Farzaneh Ghassabi1, Arghavan Haj-Sheykholeslami4
1- Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
2- Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. , tmhashempour@yahoo.com
3- Biology Department, Payame Noor University, Iran.
4- Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Abstract:   (4042 Views)

Background & Objective: Hepatitis C Virus (HCV) is one of the important risk factors for liver cirrhosis and hepatocellular carcinoma. Some of the host genetic factors such as interleukin 28B (IL-28B) may influence the response to the antiviral therapy. IL28B is a member of the interferon (IFN) family which causes an antiviral response. Previous studies indicated that rs12979860 polymorphisms of the IL-28B gene can influence persistent antiviral response. Therefore, in this study, the frequency of genotypes of rs12979860 polymorphisms in two groups of healthy and HCV infected Iranian individuals were evaluated.

Materials & Methods: In this cross sectional study, PCR-RFLP method was used to evaluate the frequency of genotypes of rs12979860 polymorphisms in 105 healthy individuals and 105 chronic HCV infected patients.

Results: The frequency of rs12979860 genotypes in healthy individuals was CC: 50.5%, CT: 45.7%, and TT: 3.8%. In HCV infected patients it was CC: 22.9%, CT: 63.8%, and TT: 13.3%. The frequency of rs12979860 genotypes had significant difference between two groups however it is not associated with sex.

Conclusion: A significant difference was observed between healthy individuals and HCV infected patients in the frequency of rs12979860 genotypes. The favorable CC genotypes and unfavorable TT genotypes was more detected in healthy individuals and HCV infected patients, respectively.

Keywords: Hepatitis C Virus, Interlukin-28, PCR-RFLP
Full-Text [PDF 975 kb]   (1135 Downloads)    
Type of Study: Research | Subject: Virology
Received: 2015/02/8 | Accepted: 2015/07/4 | Published: 2015/09/22
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Alborzi A, Hashempour T, Mirhoseini M, Adim N, Moayedi J, Musavi Z, et al . Studying the Frequency of Favorable Allele of rs12979860 Polymorphism of IL-28B in Healthy and HCV Infected Iranian Individuals. J Fasa Univ Med Sci. 2015; 5 (2) :269-277
URL: http://journal.fums.ac.ir/article-1-641-en.html
Volume 5, Number 2 (Summer 2015) Back to browse issues page
Journal of Fasa University of Medical Sciences
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