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:: Volume 5, Number 3 (Autumn 2015) ::
J Fasa Univ Med Sci 2015, 5(3): 435-443 Back to browse issues page
comparison of serum visfatin levels in restricted diet rats,type2 diabetic rats and insulin resistance rats with normal rats
dr mohammadali ghaffari1, dr zahra salemi 2, dr mohammadtaghi goodarzi3, student marzieh ghaasemi4, student elham rafee5
1- assosiated professor ahvaz university of medical science
2- assistant professor arak university of medical science , Dr.zsalemi@arakmu.ac.ir
3- professor hamedan university of medical science
4- MSc ahvaz university of medical science
5- MSc arak university of medical science
Abstract:   (3635 Views)

Background and Purpose: Adipose tissue is not only a site of triglycerides storage, but also an active endocrine organ that secretes many biologically active mediators refered to as "adipokines". Visfatin, as a new adipokine has an important role in Homeostasis of energy and glucose metabolism. In the present study serum visfatin levels in restricted diet rats,type2 diabetic rats and insulin resistant rats has been measured and compared with control group. relationship between Visfatin and blood sugar, lipid profile, insulin, and HOMA-IR in these groups has been investigated Methods and Materials: 32 male wistar rats were divided into 4 groups (8 rats in each group).group 1 was control,with free access to diet, group 2 or restricted diet group using 65% of normal diet , group3 orinduced type2 diabetic group with nicotinamide and streptozocin and group 4 was insulin resistance ,induced with fructose diet. After 6 weeks animals weight and other biochemical factors such as FBS (Fasting Blood Sugar), lipid profile, insulin and visfatin were measured. Results of this study were analyzed using SPSS16.and then examined and reported as ±average of standard deviation. Values of p< 0.05 were considered statistically significant . Results: Results of this study showed that body weight increased in all groups except diabetic group. Triglyceride were increased in all groups, in this order,restricted diet, control, insulin resistance and diabetic groups. visfatin, insulin, and Homa-IR increase significantly in type 2 diabetic rats and insulin resistant group. Conclusion: There was a positive and significant relationship between visfatin and HOMA-IR, and between visfain and FBS (Fasting Blood Sugar), while there was a negative relationship between visfatin and insulin, but this relationship was not significant.

Keywords: Type 2 diabetes, Insulin Resistance, Rat, Visfatin, HOMA-IR
Full-Text [PDF 797 kb]   (1179 Downloads)    
Type of Study: Research | Subject: Biochemistry
Received: 2015/06/7 | Accepted: 2015/09/16 | Published: 2015/12/20
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ghaffari M, salemi Z, goodarzi M, ghaasemi M, rafee E. comparison of serum visfatin levels in restricted diet rats,type2 diabetic rats and insulin resistance rats with normal rats . J Fasa Univ Med Sci. 2015; 5 (3) :435-443
URL: http://journal.fums.ac.ir/article-1-659-en.html
Volume 5, Number 3 (Autumn 2015) Back to browse issues page
Journal of Fasa University of Medical Sciences
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