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:: Volume 5, Number 1 (Spring 2015) ::
J Fasa Univ Med Sci 2015, 5(1): 142-154 Back to browse issues page
Protective Effect of Wheat Germ Oil on Sex Hormones Disorders and Uterine Tissue Disorders Morphology Following Treatment with Carbamazepine in Epileptic Female Mice with Pentylenetetrazol
Elham Ahmadi 1, Vahid Nejati2, Gholamreza Najafi3, Shiva Khezri2
1- Department of Biology, Faculty of Science, Urmia University, Urmia, Iran. , e.ahmadi9921@gmail.com
2- Department of Biology, Faculty of Science, Urmia University, Urmia, Iran.
3- Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Abstract:   (5148 Views)

 

Background & Objective: Epilepsy is one of the common neurological diseases and carbamazepine is an antiepileptic drug that causes oxidative stress, endocrine and the reproductive system long term disorders. The aim of this study is to evaluate the effect of wheat germ oil, as a rich source of antioxidants on sex hormones and uterine tissue in epileptic mice treated with carbamazepine.

Materials & Methods: In this study 48 adult female mice were randomly divided into 6 groups (n=8). Including: 1- control. 2- received pentylenetetrazol at dose of 40 (seizure control). 3- received pentylenetetrazol + carbamazepine at dose of 30. 4- received pentylenetetrazol + carbamazepine at dose of 180. 5- received pentylenetetrazol + carbamazepineat dose of 30 + wheat germ ‌oil receiver at dose of 500. 6- received pentylenetetrazol + carbamazepine at dose of 180 + wheat‌ germ ‌oil at dose of 500.(units of doses are as grams/kilogram of body weight). At the end of the treatment period, ELISA method was used to measure estrogen, progesterone and testosterone levels . In addition, histological studies were performed on the uterus. Data were analyzed using ANOVA and Tukey's test in SPSS20 software.

 

Results: Carbamazepine levels of estrogen, progesterone, testosterone, and except of myometrium, the uterine thickness and average uterine glands decreased significantly. In the group with wheat germ oil  + carbamazepine (30, 180), levels of mentioned factors changed near-normal significantly.

 

Conclusion: Results showed that the wheat germ oil improves reproductive system performance and reduces the complication of carbamazepine.  

Keywords: Uterine, Sex hormones, Wheat germ oil, Carbamazepine, Epilepsy
Full-Text [PDF 1522 kb]   (1178 Downloads)    
Type of Study: Research | Subject: Histology
Received: 2014/11/2 | Accepted: 2015/01/27 | Published: 2015/06/20
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Ahmadi E, Nejati V, Najafi G, Khezri S. Protective Effect of Wheat Germ Oil on Sex Hormones Disorders and Uterine Tissue Disorders Morphology Following Treatment with Carbamazepine in Epileptic Female Mice with Pentylenetetrazol. J Fasa Univ Med Sci. 2015; 5 (1) :142-154
URL: http://journal.fums.ac.ir/article-1-673-en.html
Volume 5, Number 1 (Spring 2015) Back to browse issues page
Journal of Fasa University of Medical Sciences
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