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:: Volume 5, Number 4 (Winter 2016) ::
J Fasa Univ Med Sci 2016, 5(4): 526-533 Back to browse issues page
The effects of hydroalcoholic extract of dracocephalum kotschyi on blood glucose and lipid profile in diabetic rats
Majid Eskandari1, Jamshid Mohammadi 2, Hamdollah Delaviz3, Ebrahim Hossieni1
1- Department of Physiology, Islamic Azad University, Fars Science and Research Branch, Shiraz, Iran.
2- Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. , j_mohammadi2005
3- Cellular and Molecular Research Centre, Yasuj University of Medical Sciences, Yasuj, Iran.
Abstract:   (4012 Views)

Background & Objective: Diabetes mellitus has different side effects on various tissues of the body. This study was conducted to determine the effect of hydroalcoholic extract of Dracocephalum kotschyi on blood glucose and lipid profile of streptozotocin-induced diabetic rats.

Materials & Methods: In this experimental study, 48 male Wistar rats (200-250 g) randomly divided into 6 equal groups. Normal control and control diabetic received distilled water, whereas the control group received the hydroalcoholic extract of Dracocephalum kotschyi (120 mg/Kg bw). Three treatment diabetic groups received 40, 80 and 120 mg/Kg bw of hydroalcoholic extract of Dracocephalum kotschyi, respectively. All rats were treated orally by gavage which continued daily for 21 days. The level of blood glucose and lipid profile was measured at the end of the study in different groups.

Results: The Mean blood glucose in the extract treatment groups decreased significantly compared to the diabetic control. The mean of total cholesterol in the treatment groups with 80 and 120 mg/Kg bw of the extract were 105.8±9.73 and 102.73±8.75 mg/dl respectively, that reduced significantly compared to the diabetic control (135.2±12.15 mg/dl). The mean of triglyceride in the treatment groups with 80 and 120 mg/Kg bw of the extract were 177.81±13.47 and 164.86±12.53 mg/dl that reduced significantly compared to the diabetic control (206.75±17.42 mg/dl).

Conclusion: The extract of Dracocephalum kotschyi probably has reduced the blood glucose and lipid profile in diabetic mellitus.

Keywords: Diabetes mellitus, Dracocephalum kotschyi, Glucose, Lipid profile
Full-Text [PDF 894 kb]   (1053 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2015/07/16 | Accepted: 2016/01/5 | Published: 2016/03/5
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Eskandari M, Mohammadi J, Delaviz H, Hossieni E. The effects of hydroalcoholic extract of dracocephalum kotschyi on blood glucose and lipid profile in diabetic rats. J Fasa Univ Med Sci. 2016; 5 (4) :526-533
URL: http://journal.fums.ac.ir/article-1-752-en.html
Volume 5, Number 4 (Winter 2016) Back to browse issues page
Journal of Fasa University of Medical Sciences
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