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:: Volume 5, Number 3 (Autumn 2015) ::
J Fasa Univ Med Sci 2015, 5(3): 397-404 Back to browse issues page
The Perinatal Effects of Lithium Carbonate on Hypothalamic-Pituitary-Gonadal in Adult Female Wistar Rats
ebrahim hosseini 1, zahra dalaeli2
1- Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran. , ebrahim.hossini@yahoo.com
2- Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
Abstract:   (4640 Views)

Background & Objectives: Lithium is the metal used in bipolar disorder treatment.  As for the prevalence of the disorder infertility (childbearing) age and the use of lithium, this study aimed at studying the effects of drugs on histological changes, and the ovarian function in the first generation of adult female offspring was performed.

Materials & Methods: In this experimental study, 40 pregnant mice were divided into 5 groups of 8, including a control group. The control and the experimental groups consumed three dosages of 60, 120, and 180 mg/kg lithium carbonate for 21 days. At the end of the sixth week postpartum, 10 mice were randomly selected from the offspring in each group and were then phlebotomized in order to measure the estrogen, progesterone, FSH, and LH hormones. Their ovaries were removed, and after preparing and staining the tissue sections, the types of follicles were counted. The results were analyzed using SPSS-18 software and ANOVA and Tukey's tests. Finally, the significant difference of data P  0/05 was considered.

Results: The results showed that lithium caused a significant increase in the number of atresia follicles and a reduction in primordial, primary, and secondary follicles, graph and corpus luteum, estrogen, progesterone, FSH, and LH hormones in the first generation offspring at P&le 0/05.

Conclusion: Using lithium during pregnancy led to an increase in the atresia follicle and a decrease in other follicles in the first generation offspring moreover, the sex hormone levels also decreased probably due to the reduction in the follicle and corpus luteum.

Keywords: Lithium, Ovarian follicles, Estrogen, Progesterone, FSH, LH
Full-Text [PDF 986 kb]   (969 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2015/02/20 | Accepted: 2015/07/11 | Published: 2015/12/8
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hosseini E, dalaeli Z. The Perinatal Effects of Lithium Carbonate on Hypothalamic-Pituitary-Gonadal in Adult Female Wistar Rats. J Fasa Univ Med Sci. 2015; 5 (3) :397-404
URL: http://journal.fums.ac.ir/article-1-760-en.html
Volume 5, Number 3 (Autumn 2015) Back to browse issues page
Journal of Fasa University of Medical Sciences
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