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:: Volume 5, Number 3 (Autumn 2015) ::
J Fasa Univ Med Sci 2015, 5(3): 347-355 Back to browse issues page
Investigating the Effect of Endurance Training on Tumor Level of IL-8 and Serum Level of IL-17 in Female Mice with Breast Cancer
AR Kazemi1, H Agha Alinejad 2, R Eslami3, P Ehsan4, R Baghaei4, R Dabaghzadeh5, M Ghanbarzadeh5
1- Department of Physical Education and Sport Sciences, School of Humanities, Vali-e-Asr University, Rafsanjan and Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
2- Department of Physical Education and Sport Sciences, faculty of Humanities, Tarbiat Modares University, Tehran, Iran , halinejad@modares.ac.ir
3- Department of Physical Education and Sport Sciences, faculty of Humanities, Allameh Tabatabaie University, Tehran, Iran
4- Department of exercise physiology, faculty of Humanities, Islamic Azad University, Kerman, Iran
5- Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Abstract:   (4730 Views)

Background & Objectives: Breast cancer is nowadays one of the most harmful threats to women’s health. However, exercise training plays an adjuvant role in breast cancer (Adjuvant also means preventive. So, no need to repeat preventing.). Therefore, the aim of this study is to investigate the effect of 6-week endurance training on the levels of interleukin-8 in the tumor and Interleukin-17 in the serum of mice suffering from breast cancer.

 Materials & Methods: In this study, 20 female Balb/C mice were randomly divided into exercise-tumor (RET) and rest-tumor (RRT) groups. The mice were oriented in the environment, and one million estrogen-dependent breast cancer cells (MC4L2) were injected into the top of the right thigh of each mouse. Subsequently, the RET group performed the endurance exercise 5 days per week for 6 weeks. The tumor volume was measured by a digital caliper each week. Finally, the mice were sacrificed, and the tumor tissue was removed and kept in -70°C. Then, ELISA method was performed and the data were collected.

Results: After 6 weeks of training, a significant decrease was observed in the RTE group in the serum level of IL-17 and IL-8 protein in tumor (P< 0.05). These results were consistent with the tumor growth rate.

Conclusion: The findings of the present study indicate that endurance training can reduce IL-8 and IL-17 proteins in the tumor and serum of mice ill with breast cancer. Therefore, the physical activity is utilized as an important factor in the improvement of adjutant therapy along with other therapeutic methods to treat breast cancer.

Keywords: Endurance training, Interleukin 8 (IL-8), Interleukin 17 (IL-17), Breast cancer
Full-Text [PDF 804 kb]   (1450 Downloads)    
Type of Study: Research | Subject: Oncology
Received: 2015/05/25 | Accepted: 2015/08/16 | Published: 2015/11/14
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Kazemi A, Agha Alinejad H, Eslami R, Ehsan P, Baghaei R, Dabaghzadeh R et al . Investigating the Effect of Endurance Training on Tumor Level of IL-8 and Serum Level of IL-17 in Female Mice with Breast Cancer. J Fasa Univ Med Sci. 2015; 5 (3) :347-355
URL: http://journal.fums.ac.ir/article-1-801-en.html
Volume 5, Number 3 (Autumn 2015) Back to browse issues page
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