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:: Volume 6, Number 1 (Spring 2016) ::
J Fasa Univ Med Sci 2016, 6(1): 52-59 Back to browse issues page
Klebsiella pneumoniae Infections in Hospitalized Patients: Characterization of Antibiotic Cross-resistance and Detection of Cefepime Susceptible-dose Dependent (SDD) Strains
Gholamreza Pourali Sheshblouki1, Jalal Mardaneh 2, Zahra Hosseinzadeh3
1- MSc Department of Microbiology, Fars Science and Research Branch, Islamic Azad University, Shiraz, Iran
2- PhD Department of Microbiology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran , Jalalmardaneh@yahoo.com
3- Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (2587 Views)

Background & Objective: Klebsiella pneumonia (K. pneumoniae) is a Gram-negative enteric bacterium that causes nosocomial infections. The aims of the present study were to identify the Klebsiella pneumoniae infections in hospitalized patients: the characterization of cross-resistance and antibiotic resistance patterns in isolates and the detection of cefepime susceptible-dose dependent in strains.
Materials & Methods: In the present study (during 2014-2015), samples were collected from patients hospitalized in Ghotbadden, Faghihi and Nemazee hospitals (Shiraz, Iran). The isolates were identified as K. pneumoniae, based on the biochemical tests embedded in the API-20E system. The susceptibility testing (disc diffusion) was performed according to the clinical and laboratory standards institute guidelines (CLSI 2014). The dDetection of cefepime susceptible-dose dependent (SDD) was performed. The detection of AmpC β-lactamases producing strains was done based on the cefoxitin and cefepime disk tests.
Results: In this study 111 strains of Klebsiella pneumoniae were isolated. The less effective drug was ceftazidime (37.8% were sensitive). All SDD strains were susceptible to colistin and imipenem. Colistin (96.4%) and imipenem (88.3%) were the most effective antibiotics against isolates. Respectively, 41.4% and 35.1% isolates displayed resistance to gentamicin and amikacin. All colistin resistant isolates were imipenem sensitive.
Conclusion: Carbapenem drugs are effective against Klebsieella pneumoniae infections. These results indicate that multidrug-resistant strains of K. pneumoniae are rising. The routine investigation and reporting of antibiotics resistance profile in patients presenting with Klebsiella infections is suggested.

Keywords: Hospitalized patients, Bacterial infection, Klebsiella pneumoniae, Antibiotic resistance pattern, Susceptible-dose dependent
Full-Text [PDF 909 kb]   (972 Downloads)    
Type of Study: Research | Subject: Microbiology
Received: 2015/09/21 | Accepted: 2016/02/11 | Published: 2016/06/17
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Pourali Sheshblouki G, Mardaneh J, Hosseinzadeh Z. Klebsiella pneumoniae Infections in Hospitalized Patients: Characterization of Antibiotic Cross-resistance and Detection of Cefepime Susceptible-dose Dependent (SDD) Strains. J Fasa Univ Med Sci. 2016; 6 (1) :52-59
URL: http://journal.fums.ac.ir/article-1-818-en.html
Volume 6, Number 1 (Spring 2016) Back to browse issues page
Journal of Fasa University of Medical Sciences
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