[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Submit :: Contact Us ::
:: Volume 5, Number 4 (Winter 2016) ::
J Fasa Univ Med Sci 2016, 5(4): 460-469 Back to browse issues page
Evaluating Blood Parameters, P53, and IL6 in Personnel of Copper Complex: A Comparison with Control Group
Hadis Ahmadiraad1, Mina Hemmati2, Mehdi Mahmodi1, Ahmadreza Sayadi Anari3, Mohammadreza Mirzaee1, Alireza Khoshdel4, Maryam Amiri5, Fahimmeh MohammadainShahrbabaki1, Mohammadreza Hajizade 6
1- Molecular medicine research center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
2- Department of Clinical Biochemical, Medical School, Birjand University of Medical Sciences, Birjand, Iran.
3- Social Determinants of Mental Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran,
4- Department of Clinical Biochemical, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
5- Department of Clinical Biochemical, ShaahidBeheshti University of Medical Sciences, Tehran, Iran.
6- Molecular medicine research center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , hajizadehus@yahoo.com
Abstract:   (4692 Views)

Background & Objectives: Industrial pollution including trace elements is the ability to exert many biological effects such as cancer and inflammatory diseases on humans. Therefore, in this study, some of the inflammation and cancer awareness factors such as P53 and IL6 and some blood indices are examined along with trace elements to which people are normally exposed.

Materials & Methods: The population includes 45 workers subjected to trace elements who are studied in comparison with the control group with some biochemical parameters such as WBC, RBC, and CRP. In addition, gene expressions of p53 and IL6 are measured by Real time PCR technique.

Results: The results show that the gene expressions of IL6 and P53 increases significantly (P –Value p53=0.00, IL6=0.0037). Furthermore, the number of red and white blood cells demonstrate a substantial upsurge. The level of liver enzymes of ALT and AST grows. Additionally, ALP reduces and CRP is negative in all the subjects. (P = 0.001).

Conclusion: The results confirm that industrial pollution is able to induce some changes in gene expressions of P53, IL6, and some blood parameters. It may create serious risks for people who will be exposed to pollution in the future.

Keywords: Industrial pollution, Trace elements, IL6, P53
Full-Text [PDF 912 kb]   (1656 Downloads)    
Type of Study: Research | Subject: Biochemistry
Received: 2015/08/16 | Accepted: 2015/09/30 | Published: 2016/01/23
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ahmadiraad H, Hemmati M, Mahmodi M, Sayadi Anari A, Mirzaee M, Khoshdel A, et al . Evaluating Blood Parameters, P53, and IL6 in Personnel of Copper Complex: A Comparison with Control Group. J Fasa Univ Med Sci. 2016; 5 (4) :460-469
URL: http://journal.fums.ac.ir/article-1-889-en.html
Volume 5, Number 4 (Winter 2016) Back to browse issues page
Journal of Fasa University of Medical Sciences
Persian site map - English site map - Created in 0.048 seconds with 811 queries by yektaweb 3503