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:: Volume 1, Issue 4 (Winter 2012) ::
J Fasa Univ Med Sci 2012, 1(4): 187-191 Back to browse issues page
Evaluation of Apolipoprotein A5 Polymorphism in Coronary- Heart Disease Patients
Somayeh Haqparast , Peyman Izadpanah, Abbas Abdollahi, Sohrab Najafipoor, Yaser Mansoori, Seyed Amin Koohpayeh, Mehdi Fasihi Radmandi
Abstract:   (15558 Views)
Background and Objectives: Apolipoprotein A5 (APOA5) gene is important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. Mutation in this gene affected plasma triglyceride level. We looked for possible associations of the APOA5 gene polymorphism S19W with coronary heart disease (CHD) in a sample of Iranian population.
Materials and Methods: A total of 73 CHD patients and 55 controls were genotyped by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) for this single nucleotide polymorphism. Serum lipids and Fast Blood Sugar concentrations were measured in all subjects with enzymatic method.
Results: Allele frequencies observed in our population were 0.041 for the W allele and 0.959 for the S allele which are similar to other populations (p>0.05). There is no evidence that APOA5 S19W, is a risk factor of CHD in our sample (p>0.05). In addition, we observed no association between the APOA5 W allele and elevated plasma TG levels (p>0.05) in the CHD group. This result was also present in the control group (p>0.05).
Conclusion: The APO A5 gene polymorphism in S19W gene has no association with the high susceptibility to CHD.
Keywords: Keywords: Apolipoprotein A5, Coronary heart disease, Polymorphism, PCR-RFLP
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Type of Study: Research | Subject: Medical Genetics
Received: 2013/02/11 | Accepted: 2013/09/14 | Published: 2013/09/14
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Haqparast S, Izadpanah P, Abdollahi A, Najafipoor S, Mansoori Y, Koohpayeh S A et al . Evaluation of Apolipoprotein A5 Polymorphism in Coronary- Heart Disease Patients. J Fasa Univ Med Sci. 2012; 1 (4) :187-191
URL: http://journal.fums.ac.ir/article-1-94-en.html


Volume 1, Issue 4 (Winter 2012) Back to browse issues page
Journal of Fasa University of Medical Sciences
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