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:: Volume 6, Number 2 (Summer 2016) ::
J Fasa Univ Med Sci 2016, 6(2): 162-168 Back to browse issues page
Evaluation of The Antibacterial Effects of The New Benzothiazole and Tetrahydropyrimidine Derivatives against Streptococcus Iniae, Edwardsiella Tarda and Aeromonas Hydrophila as Some Zoonotic Bacterial Pathogens
Reza Aryan 1, Behzad Ghasemi2, Hamid Beyzaei3, Mohsen Najimi4
1- Assistant Professor Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran. , rezaaryanchemist@yahoo.com
2- M.D. Department of Pathobiology, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran.
3- Assistant Professor Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran.
4- Assistant Professor Department of Pathobiology, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran.
Abstract:   (1966 Views)

Background & Objective: The novel stronger antibacterial compounds such as the thiazole and pyrimidine derivatives are needed in order to remove the threat of bacterial antibiotic resistance in zoonotic aquatic bacterial pathogens. In this study, we evaluated the inhibitory effect of the new benzothiazole and tetrahydropyrimidine derivatives against three important zoonotic aquatic pathogens including Streptococcus iniae, Edwardsiella tarda and Aeromonas hydrophila.

Material & Methods: Benzothiazole and tetrahydropyrimidine derivatives were synthesized and dissolved in DMSO with a concentration of 8129 μg/mL. Then, the disk diffusion and broth microdilution methods were applied to evaluate the antibacterial effects. Results were recorded as the minimum inhibitory concentration (MIC) and the growth inhibition zone diameter.

Results: The study showed that the two tetrahydropyrimidine derivatives had no inhibition effects on all of the studied bacteria. Moreover, no inhibitory effect was observed from the three banzothiazole derivatives against A. hydrophila. However, the benzothiazole derivatives showed significant inhibitory effect against S. iniae and E. tarda with MIC of 256-1024 µg/mL and the growth inhibition zone diameter of 4.3±0.3-18.2±0.1 mm.

Conclusion: The antibacterial effect of the new banzothiazole derivatives was confirmed on S. iniae and E. tarda pathogens for the first time.  

Keywords: Antibacterial, Zoonotic Bacteria, Benzothiazole and tetrahydropyrimidine
Full-Text [PDF 1097 kb]   (852 Downloads)    
Type of Study: Research | Subject: Microbiology
Received: 2015/11/4 | Accepted: 2016/02/10 | Published: 2016/09/10
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Aryan R, Ghasemi B, Beyzaei H, Najimi M. Evaluation of The Antibacterial Effects of The New Benzothiazole and Tetrahydropyrimidine Derivatives against Streptococcus Iniae, Edwardsiella Tarda and Aeromonas Hydrophila as Some Zoonotic Bacterial Pathogens. J Fasa Univ Med Sci. 2016; 6 (2) :162-168
URL: http://journal.fums.ac.ir/article-1-951-en.html
Volume 6, Number 2 (Summer 2016) Back to browse issues page
Journal of Fasa University of Medical Sciences
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