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:: Volume 6, Number 4 (Winter 2017) ::
J Fasa Univ Med Sci 2017, 6(4): 530-537 Back to browse issues page
The Healing Effect of Hydroalcoholic Extract of Hypericum Perforatum on Acetic Acid-Induced Ulcerative Colitis in Male Rats
Nader Tanideh1, Seyyedeh Leila Nematollahi 2, Seyyed Vahid Hosseini3, Masoud Hosseinzadeh4, Davood Mehrabani1, Alireza Safarpour5, Sepehrimanesh Masoud5, Omid Koohi Hosseinabadi6, Asma Najibi7
1- Stem Cell and Transgenic Technology Research Center, Department of Pharmacology Shiraz University of Medical Sciences, Shiraz, Iran
2- Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran , sl.nematollahi@gmail.com
3- Colorectal research, Shiraz University of Medical Sciences, Shiraz, Iran
4- Department of pathology, Shiraz University of Medical Sciences, Shiraz, Iran
5- Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
6- Center of Experimental and Comparative Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
7- Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (2055 Views)

Background & Objective: Anti-inflammatory effect of Hypericum have long been considered. Ulcerative Colitis (UC) is a form of Inflammatory Bowel Disease (IBD). In this study, the effects of Hypericum perforatum on histopathological changes and tissue malondialdehyde (MDA) level of colonic tissue in rats with induced UC were evaluated.

Materials & Methods: 70 rats were divided into seven equal groups. Colitis was induced by acetic acid.. Groups I and II received 1 mL of 600 and 300 mg/kg H. perforatum extract orally per day respectively; groups III and IV received 1 mL of 20% and 10% intra-colonic gel form of H. perforatum extract daily respectively; group V, as positive control, received 1 mL of intra-colonic Asacol; group VI received 1 mL of normal saline as negative control; group VII received just intra-colonic gel base. All the animals were evaluated for histological changes and tissue MDA level of colon seven days after the treatment.

Results: H. perforatum extract in the two forms of trans-rectal and oral administration could result in a more healing effect on acetic acid-induced damaged colonic tissue with a reduction in the MDA activity. In trans-rectal administration, the 20% gel had a better healing response than the 10% gel. In oral administration, the 600 mg/kg dosage had a better healing response than the 300 mg/kg.

Conclusions: Therefor, H. perforatum can be considered as a treatment of choice for UC especially in trans-rectal gel form.

Keywords: hypericum perforatum, inflammatory bowel disease, ulcerative colitis, Malondialdehyde
Full-Text [PDF 1384 kb]   (543 Downloads)    
Type of Study: Research | Subject: Pharmacology
Received: 2016/04/13 | Accepted: 2016/08/15 | Published: 2017/03/8
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Tanideh N, Nematollahi L, Hosseini V, Hosseinzadeh M, Mehrabani D, Safarpour A, et al . The Healing Effect of Hydroalcoholic Extract of Hypericum Perforatum on Acetic Acid-Induced Ulcerative Colitis in Male Rats. J Fasa Univ Med Sci. 2017; 6 (4) :530-537
URL: http://journal.fums.ac.ir/article-1-978-en.html
Volume 6, Number 4 (Winter 2017) Back to browse issues page
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