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:: Volume 6, Issue 4 (Winter 2017) ::
J Fasa Univ Med Sci 2017, 6(4): 530-537 Back to browse issues page
The Healing Effect of Hydroalcoholic Extract of Hypericum Perforatum on Acetic Acid-Induced Ulcerative Colitis in Male Rats
Nader Tanideh 1, Leila Nematollahi Seyyedeh 2, Vahid Hosseini Seyyed3, Masoud Hosseinzadeh 4, Davood Mehrabani 1, Alireza Safarpour 5, Sepehrimanesh Masoud 5, Omid Koohi Hosseinabadi 6, Asma Najibi 7
1- Stem Cell and Transgenic Technology Research Center, Department of Pharmacology Shiraz University of Medical Sciences, Shiraz, Iran
2- Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran , sl.nematollahi@gmail.com
3- Colorectal research, Shiraz University of Medical Sciences, Shiraz, Iran
4- Department of pathology, Shiraz University of Medical Sciences, Shiraz, Iran
5- Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
6- Center of Experimental and Comparative Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
7- Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (2457 Views)

Background & Objective: Anti-inflammatory effect of Hypericum have long been considered. Ulcerative Colitis (UC) is a form of Inflammatory Bowel Disease (IBD). In this study, the effects of Hypericum perforatum on histopathological changes and tissue malondialdehyde (MDA) level of colonic tissue in rats with induced UC were evaluated.

Materials & Methods: 70 rats were divided into seven equal groups. Colitis was induced by acetic acid.. Groups I and II received 1 mL of 600 and 300 mg/kg H. perforatum extract orally per day respectively; groups III and IV received 1 mL of 20% and 10% intra-colonic gel form of H. perforatum extract daily respectively; group V, as positive control, received 1 mL of intra-colonic Asacol; group VI received 1 mL of normal saline as negative control; group VII received just intra-colonic gel base. All the animals were evaluated for histological changes and tissue MDA level of colon seven days after the treatment.

Results: H. perforatum extract in the two forms of trans-rectal and oral administration could result in a more healing effect on acetic acid-induced damaged colonic tissue with a reduction in the MDA activity. In trans-rectal administration, the 20% gel had a better healing response than the 10% gel. In oral administration, the 600 mg/kg dosage had a better healing response than the 300 mg/kg.

Conclusions: Therefor, H. perforatum can be considered as a treatment of choice for UC especially in trans-rectal gel form.

Keywords: hypericum perforatum, inflammatory bowel disease, ulcerative colitis, Malondialdehyde
Full-Text [PDF 1384 kb]   (630 Downloads)    
Type of Study: Research | Subject: Pharmacology
Received: 2016/04/13 | Accepted: 2016/08/15 | Published: 2017/03/8
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Tanideh N, Nematollahi L, Hosseini V, Hosseinzadeh M, Mehrabani D, Safarpour A, et al . The Healing Effect of Hydroalcoholic Extract of Hypericum Perforatum on Acetic Acid-Induced Ulcerative Colitis in Male Rats. J Fasa Univ Med Sci. 2017; 6 (4) :530-537
URL: http://journal.fums.ac.ir/article-1-978-en.html


Volume 6, Issue 4 (Winter 2017) Back to browse issues page
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