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:: Volume 10, Issue 2 (Summer 2020) ::
J Fasa Univ Med Sci 2020, 10(2): 2362-2370 Back to browse issues page
Correlation of Serum Resistin Level with Insulin Resistance and Metabolic Parameters in Patients with Type 2 Diabetes and Prediabetes
Nilofar Sayar1 , Masoumeh Nezhadali 2, Mehdi Hedayati3 , Maryam Mahdavi4 , Mahdi Akbarzadeh3 , Maryam Zarkesh5
1- Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran
2- Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran , ma_ nejadali@yahoo.com
3- Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran
4- Obesity research center, Research institute for endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5- SCellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran
Abstract:   (999 Views)
Background &Objective: Resistin an adipocytokines secreted by adipocytes, is associated with insulin resistance and increases in obesity, cardiovascular disease and other inflammatory diseases. The aim of this study was to investigate the relationship between resistin levels, metabolic variables, and insulin resistance in patients with prediabetes / diabetes in an Iranian population.
Material& Methods: This study was conducted on 75 patients with fasting plasma glucose (FPG)≥ 100 mg/dl in prediabet­ic/ diabetic group and 75 participants with FPG less than 100 mg/dl as control group. Plasma levels of resistin and insulin were measured by ELISA kit and other variables were determined by standard methods. Statistical analysis was performed using SPSS softwareversion 19.
Results: Resistin levels, body mass index, triglyceride, cholesterol, FPG and insulin resistance were significantly higher in patients with pre-diabetes / diabetes compared with controls (P-value <0.05). Serum resistin level was positively correlated with body mass index, FPG and insulin resistance (P-value <0.05). Reverse correlations were found between resistin and HDL (P-value <0.05).
Conclusion: Higher levels of resistin in patients with type 2 diabetes / pre-diabetes in our study and significant association of resistin with glucose, insulin resistance, and BMI, indicate the pathophysiological role of this adipokin in the development of type 2 diabetes.
 
 
Keywords: Resistin, Insulin resistance, Type 2 diabetes
Full-Text [PDF 1087 kb]   (241 Downloads)    
Type of Study: Research | Subject: Biochemistry
Received: 2019/09/1 | Accepted: 2020/01/25 | Published: 2020/09/19
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Sayar N, Nezhadali M, Hedayati M, Mahdavi M, Akbarzadeh M, Zarkesh M. Correlation of Serum Resistin Level with Insulin Resistance and Metabolic Parameters in Patients with Type 2 Diabetes and Prediabetes. J Fasa Univ Med Sci. 2020; 10 (2) :2362-2370
URL: http://jabs.fums.ac.ir/article-1-2108-en.html


Volume 10, Issue 2 (Summer 2020) Back to browse issues page
Journal of Fasa University of Medical Sciences
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