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:: Volume 9, Issue 2 (summer 2019) ::
J Fasa Univ Med Sci 2019, 9(2): 1357-1367 Back to browse issues page
The Role of Sperm Protamine in Pathogenesis of Male Infertility
Marzieh Tavalaee 1, Razieh Ghorbani2 , Mohammad hossein Nasr-Esfahani2
1- Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran , tavalaee.m@royaninstitute.org
2- Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
Abstract:   (261 Views)
Background & Objective: Approximately 40-50% of infertility is due to male factor infertility that abnormal sperm chromatin structure as a major cause of infertility has been suggested. Protamines are the major components of sperm chromatin and play a central role in the correct chromatin packaging. Several studies have shown that the protamine deficiency in sperm is associated with low sperm quality and infertility. Considering the importance of protamine infertility, the purpose of this review article was to study the protamine content and it’s biological significance in male fertility.
Materials & Methods: Published papers by researchers in the Google Scholar, Science Direct and PubMed databases were collected from 1874 to 2018, and the best and most efficient papers were considered for this study.
Results: Several studies have shown that there is a significant reverse relationship between protamine deficiency in sperm with fertilization and pregnancy rate following assisted reproduction techniques and central cause of protamine deficiency in sperm is due to the increase of oxidative stress which consequently causes to DNA damage.
Conclusion: Treatment with antioxidants can reduce oxidative stress in infertile men, and improve sperm parameters, sperm protamine content, and DNA integrity.
 
 
Keywords: Protamine, Male Infertility, spermatogenesis
Full-Text [PDF 812 kb]   (25 Downloads)    
Type of Study: Review | Subject: other
Received: 2018/10/31 | Accepted: 2019/05/12 | Published: 2019/09/18
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tavalaee M, ghorbani R, Nasr-Esfahani M H. The Role of Sperm Protamine in Pathogenesis of Male Infertility . J Fasa Univ Med Sci. 2019; 9 (2) :1357-1367
URL: http://journal.fums.ac.ir/article-1-1578-en.html


Volume 9, Issue 2 (summer 2019) Back to browse issues page
Journal of Fasa University of Medical Sciences
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