[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Submit :: Contact Us ::
:: Volume 8, Issue 4 (Winter 2019) ::
J Fasa Univ Med Sci 2019, 8(4): 1106-1115 Back to browse issues page
Biological Evaluation of Heterocycle Moiety of Some Novel azoles Derivatives as Antibacterial and Antifungal potential Agents
Abozar Roeintan
Department of Chemistry, Faculty of Science, University of Imam Hossein, Tehran, Iran , abroeintan@gmail.com
Abstract:   (1478 Views)
Background & Objective: Azole nucleuses are very important part of antimicrobial, analgesic and anti-inflammatory drugs. The azole class of compounds is the most popular among the antibacterial and antifungal classes because of its lower toxicity, higher efficacy and a broad spectrum of activity. Today, Efforts have focused on the development of new, less toxic and more efficacious antifungal and antibacterial drugs, with the novel mechanism of action. In this study, we tried to investigate the antibacterial and antifungal effects of the new azole derivatives.
Materials & methods: This research is a descriptive – cross sectional study. The antibacterial and antifungal activity of compounds was evaluated using the minimum inhibitory concentration (MIC) method on a series of gram positive and gram negative bacterial strains and Aspergillus niger, Aspergillus flavus, Candida albicans. The Minimum Inhibitory Concentration from the growth of this bacteria and fung ranges from 12.5 mg/ml to 200 mg/ml.
Results: Among the tested compounds, 4- Nitro, 2- methyl imidazole hetrocycle-pathic compound exerted potent in vitro antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis and Staphylococcus aureus while compounds (imidazole, benzimidazole hetrocycle-pathic compound) exhibited potent in vitro antifungal activity against Candida albicans, Aspergillus flavus and Aspergillus niger.
Conclusion: Our results indicated that the designed derivatives (4- Nitro, 2- methyl imidazole, imidazole and benzimidazole hetrocycle-pathic compounds) showed effective antibacterial and antifungal activity mainly against a series of gram positive and gram negative bacterial strains. On the other hand, the tested compounds had an appropriate spectrum effect, because they showed antibacterial effect on both positive and negative strains.
     
 
Keywords: Antibacterial Agents, Antifungal Agents, Azoles, Toxicity, Minimum Inhibitory Concentration
Full-Text [PDF 990 kb]   (219 Downloads)    
Type of Study: Research | Subject: Biochemistry
Received: 2018/02/25 | Accepted: 2018/09/15 | Published: 2019/03/17
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

roeintan A. Biological Evaluation of Heterocycle Moiety of Some Novel azoles Derivatives as Antibacterial and Antifungal potential Agents . J Fasa Univ Med Sci. 2019; 8 (4) :1106-1115
URL: http://journal.fums.ac.ir/article-1-1680-en.html


Volume 8, Issue 4 (Winter 2019) Back to browse issues page
Journal of Fasa University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 3925