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:: Volume 10, Issue 1 (Spring 2020) ::
J Fasa Univ Med Sci 2020, 10(1): 1998-2011 Back to browse issues page
Mechanisms of the Effects of Zinc Oxide Nanostructures on Living Cells
Azam Javadi1 , Maryam Farzaneh2 , Saadati Mokhtar3 , Rohollah Azimirad4 , Fereshteh Esfandiari5 , Hamid Gourabi 6
1- Department of Genetic, Faculty of Basic Science and Advanced Technologies, University of Science and Culture, Royan Institute, Tehran, Iran
2- Department of Cell & Molecular Biology, Faculty of basic science and advanced technologies, University of Science and Culture, Royan Institute, Tehran, Iran
3- Department of Physics, Shahid Beheshti University, Tehran, Iran
4- Department of Physics, Sharif University of Technology, Tehran, Iran
5- Department of Cell & Molecular Biology, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
6- Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran , gourabi@royaninstitute.org
Abstract:   (1420 Views)
Nowadays, nanotechnology and nanostructures, which are particles smaller than 100 nm in size at least in one dimension, are being widely used in various industries and consumer products, biomedical applications and environments. Unique properties of Zinc oxide (ZnO) nanostructures offer technological advantages for a variety of industrial and consumer products as well as show promise for biomedical application. They are used as an antibacterial agent in food packaging, such as UV absorbent in cosmetics and sunscreens. However, high concentrations of ZnO nanostructures have toxic effects on living organisms. The toxic effect of these nanostructures depends on target cell type, size, structure, and surface properties of nanostructures, as well as exposure routes. In this article, we discuss the toxic effect of ZnO nanostructures and different mechanisms including ROS production and the resulting oxidative stress, genomic toxicity, changes in gene expression and following protein production, epigenetic changes and inflammatory responses and apoptosis. Also, we will mention many in vivo studies about this nanoparticle.
 
 
Keywords: Nanotechnology, Zinc Oxide, Free radicals of Oxygen, Toxicity, Apoptosis
Full-Text [PDF 1406 kb]   (377 Downloads)    
Type of Study: Review | Subject: Nanomedicine
Received: 2019/05/26 | Accepted: 2019/10/20 | Published: 2020/02/27
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Javadi A, farzaneh M, Mokhtar S, Azimirad R, Esfandiari F, Gourabi H. Mechanisms of the Effects of Zinc Oxide Nanostructures on Living Cells. J Fasa Univ Med Sci. 2020; 10 (1) :1998-2011
URL: http://jabs.fums.ac.ir/article-1-2037-en.html


Volume 10, Issue 1 (Spring 2020) Back to browse issues page
Journal of Fasa University of Medical Sciences
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