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:: Volume 3, Issue 2 (Summer 2013) ::
J Fasa Univ Med Sci 2013, 3(2): 117-123 Back to browse issues page
The Role of Parabrachial GABAA Receptors in Pain Modulation in Rats
Kazem Javanmardi1, Ava Soltanihekmat 2, Masoomeh Shekoohi3, Parisa Hasanein4, Mehdi Bakhshi5, Roghayeh Ghodsi1, Leila Rezaeian6, Akhtar Bordbar1
1- Department of physiology, Fasa University of Medical Sciences, Fasa, Iran
2- Department of physiology, Fasa University of Medical Sciences, Fasa, Iran , Soltanihekmat@yahoo.com
3- Department of physiology, Jahrom Branch,, Islamic Azad University, Jahrom, Iran
4- Department of Biology, Buali Sina University, Hamedan, Iran
5- Department of Pathology, Fasa University of Medical Sciences, Fasa, Iran
6- Farhangian University. Shiraz. Iran.
Abstract:   (22997 Views)
Background & Objective: The parabrachial nucleus is a critical link in the transmission of short latency nociceptive information to midbrain neurons. GABA(A) receptors have bidirectional roles in controlling nociception and are abundant in the parabrachial region . We examined the effects of bilateral intra parabrachial microinjection of different doses of the GABA(A) receptor agonist, muscimol, and the GABA(A) receptor antagonist, bicuculline, on pain modulation using a tail-flick test .
Materials & Methods: Rats were anaesthetized with sodium pentobarbital (55 mg/kg) and then special cannulas were inserted stereotaxically into the parabrachial nucleus. After 1 week of recovery, the effects of microinjection of muscimol, (62.5, 125,250 ng/side) or bicuculline, (50,100,200 ng/side) into the parabrachial on tail flick latencies were assessed. Tail-flick latencies were measured for 60 minutes every 5 min after drug microinjection.
Results: Microinjection of muscimol (62.5, 125 ng/side) and bicuculline (50,100,200 ng/side) into the parabrachial did not have any statistically significant effect on tail-flick latency. Administration of, muscimol, (250 ng/side) produced thermal hyperalgesia (P<0.05).
Conclusion: The results of the present study showed that in this model of pain gaba a receptors in the paracrachial region are not Endogenously activated but these receptors in this region have a potential to affect pain modulation.
Keywords: Parabrachial, GABAA Receptors, Pain
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Type of Study: Research | Subject: Physiology
Received: 2013/07/22 | Accepted: 2013/10/6 | Published: 2013/10/6
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javanmardi K, soltanihekmat A, shekoohi M, hasanein P, bakhshi M, ghodsi R, et al . The Role of Parabrachial GABAA Receptors in Pain Modulation in Rats. J Fasa Univ Med Sci. 2013; 3 (2) :117-123
URL: http://jabs.fums.ac.ir/article-1-282-en.html

Volume 3, Issue 2 (Summer 2013) Back to browse issues page
Journal of Fasa University of Medical Sciences
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