Journal of Advanced Biomedical Sciences
JABS
Thu, Nov 21, 2024
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Volume 14, Issue 2 (3-2024)
JABS 2024, 14(2): 104-114 |
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Ethics code: IR.FUMS.REC.1396.219
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Pezeshki B, Torabi S M, Sedigh Rahimabadi M, Pourmontaseri H, Namjoyan F, Dabbaghmanesh M H, et al . A Complementary Therapy with Trigonella foenum-graecum L. and Citrullus colocynthis (L.) in Type 2 Diabetes Mellitus: A Double-Blind Randomized Controlled Clinical Trial. JABS 2024; 14 (2) :104-114
URL: http://jabs.fums.ac.ir/article-1-3049-en.html
URL: http://jabs.fums.ac.ir/article-1-3049-en.html
Babak Pezeshki1 
, Seyed Mohammadreza Torabi2 , Massih Sedigh Rahimabadi3 , Hossein Pourmontaseri2 , Foroogh Namjoyan4 , Mohammad Hossein Dabbaghmanesh5 , Elham Zarenezhad1 , Mehdi Sharafi6 , Mahsa Rostami chijan * 7
, Seyed Mohammadreza Torabi2 , Massih Sedigh Rahimabadi3 , Hossein Pourmontaseri2 , Foroogh Namjoyan4 , Mohammad Hossein Dabbaghmanesh5 , Elham Zarenezhad1 , Mehdi Sharafi6 , Mahsa Rostami chijan * 7
1- Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
2- Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran
3- Department of Persian Medicine, Fasa University of Medical Sciences, Fasa, Iran
4- Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
5- Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
6- Department of Community Medicine, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
7- Department of Persian Medicine, Fasa University of Medical Sciences, Fasa, Iran ,mahsa_59_2007@yahoo.com
2- Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran
3- Department of Persian Medicine, Fasa University of Medical Sciences, Fasa, Iran
4- Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
5- Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
6- Department of Community Medicine, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
7- Department of Persian Medicine, Fasa University of Medical Sciences, Fasa, Iran ,
Abstract: (341 Views)
Background & Objectives: Diabetes is a known chronic disease affecting more than 400 million people and causing millions of deaths worldwide annually. The World Health Organization predicts that by 2030, diabetes will become the seventh leading cause of death. In the last decades, numerous chemotherapy approaches have been used. However, herbal remedies have accounted for more than 70 percent of the total administered antidiabetic treatments during the last decade. In this study, we aimed to develop a novel natural antidiabetic therapy with Trigonella foenum-graecum (T. foenum-graecum) L. and Citrullus colocynthis (C. colocynthis) (L.). Based on past studies, using C. colocynthis singly can cause diarrhea, abdominal pain, and heartburn, hence in order to reduce these complications, we applied this plant in combination with T. foenum-graecum based on the recommendations of Persian medicine references.
Materials & Methods: We admitted 34 diabetics aged 30-65 years old to design a double-blind parallel randomized controlled clinical trial. We prepared therapeutic capsules containing a combination of 40 mg of C. colocynthis and 350 mg of T. foenum-graecum L. We divided participants into an interventional (n=17) and placebo (n=17) groups and measured fasting blood sugar (FBS) levels, lipid profile, and liver function tests initially. After two weeks, all participants returned for a visit, and FBS and blood sugar (BS) were measured. At the end (12th week), all outcomes were measured and analyzed using an independent t-test and Chi-squared (χ2).
Results: The FBS levels decreased significantly in the intervention group compared to that of the control group (171.8±54.9 versus 149.6±46.4, p=0.024), but the improvements in the lipid profile and liver function were not statistically significant.
Conclusion: This study unveiled that combination of T. foenum-graecum L. and C. colocynthis L. at safe levels significantly decreased the FBS levels among T2DM patients. Further studies are needed to provide more efficient antidiabetic effects with the low side effects.
Materials & Methods: We admitted 34 diabetics aged 30-65 years old to design a double-blind parallel randomized controlled clinical trial. We prepared therapeutic capsules containing a combination of 40 mg of C. colocynthis and 350 mg of T. foenum-graecum L. We divided participants into an interventional (n=17) and placebo (n=17) groups and measured fasting blood sugar (FBS) levels, lipid profile, and liver function tests initially. After two weeks, all participants returned for a visit, and FBS and blood sugar (BS) were measured. At the end (12th week), all outcomes were measured and analyzed using an independent t-test and Chi-squared (χ2).
Results: The FBS levels decreased significantly in the intervention group compared to that of the control group (171.8±54.9 versus 149.6±46.4, p=0.024), but the improvements in the lipid profile and liver function were not statistically significant.
Conclusion: This study unveiled that combination of T. foenum-graecum L. and C. colocynthis L. at safe levels significantly decreased the FBS levels among T2DM patients. Further studies are needed to provide more efficient antidiabetic effects with the low side effects.
Type of Study: Research |
Subject:
Internal Medicine
Received: 2024/02/27 | Accepted: 2024/06/12 | Published: 2024/08/6
Received: 2024/02/27 | Accepted: 2024/06/12 | Published: 2024/08/6
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This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)