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:: Volume 4, Issue 1 (Spring 2014) ::
JABS 2014, 4(1): 15-33 Back to browse issues page
Investigating the Protective Effects of Vitamin D on Diabete
Makan Cheraghpour1, Farnoosh Naghashian2, Elham Ehrampoush3, Hosein Davoodi4, Jalalaldin Mirzairazzaz5, Reza Homayounfar6
1- Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran. Iran.
2- Faculty of Health, Tehran University of Medical sciences, Tehran, Iran.
3- Shiraz university of Medical Sciences, Shiraz, Iran.
4- Department of Clinical Nutrition & Dietetics, National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5- Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
6- Department of Biochemistry, Fasa University of Medical Sciences, Fasa, Iran.
Abstract:   (34882 Views)
Vitamin D directly (due to receptor activation by vitamin D) or indirectly (through regulation of calcium homeostasis) effects on the pathogenic mechanisms associated with both types of diabetes, such as pancreatic beta-cell dysfunction, impaired insulin action and systemic inflammation. It has been shown that using Vitamin D supplementation during pregnancy and infancy has relation with a reduced risk of type 1 diabetes. In non-obese diabetic mice studies, pharmacological doses of vitamin D can delay the onset of diabetes. Any direct link between vitamin D and risk of type 2 diabetes has not been established yet, however many questions such as the concentration of vitamin D for optimal glucose homeostasis and how long pursuit to understand the effect of vitamin D on insulin secretion and sensitivity is essential have not been fully answered. The use of 1, 25 (OH) 2D3 for preventing or treating diabetes through its hypercalcemic effects and bone turnover is limited. On the other hand however, the protective effects only observed in response to doses higher than the physiological levels. In any case, a better understanding of the role of vitamin D can lead to the development of preventive strategies for both types of diabetes..
Keywords: Vitamin D, Diabetes, Glucose homeostasis, Insulin resistance.
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Type of Study: Review | Subject: Nutrition
Received: 2013/08/30 | Accepted: 2014/01/4 | Published: 2014/06/11
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Cheraghpour M, Naghashian F, Ehrampoush E, Davoodi H, Mirzairazzaz J, Homayounfar R. Investigating the Protective Effects of Vitamin D on Diabete. JABS. 2014; 4 (1) :15-33
URL: http://jabs.fums.ac.ir/article-1-321-en.html


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Volume 4, Issue 1 (Spring 2014) Back to browse issues page
Journal of Fasa University of Medical Sciences
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