Background & Objective: This study tries to explain the role of mediator between personality characteristics and coping styles is resiliency.

Material & Methods: The study population consisted of all patients is a member of the MS Society of Shiraz who were selected by convenience sampling. 3 tests were used to collect data: Connor-Davidson Resilience Scale, NEO Five-Factor personality inventory questionnaire Folkman and Lazarus coping strategies. Analysis of data obtained using SPSS (version 21) software and using Pearson correlation and regression analysis was performed.

Results: High neuroticism in MS patients reduce resiliency (r=-0.279). Also people with MS deal with emotional problems just behave. Emotional coping style (p=0.023 & b=0.429) and the personality trait of neuroticism (p=0.046 & b=0.388) are able to predict Resiliency.

Conclusion: Based on these findings, in addition to informing the people affected by psychological training, effective in reducing neuroticism, anxiety and consequently raise the level of resiliency.